Associated Papers
CCDC6-RET fusion protein regulates Ras/MAPK signaling through the fusion- GRB2-SHC1 signal niche.
Qiu T et al.
Proceedings of the National Academy of Sciences of the United States of America, 2024
A Single RET Mutation in Hirschsprung Disease Induces Intestinal Aganglionosis Via a Dominant-Negative Mechanism.
Sunardi M et al.
Cellular and Molecular Gastroenterology and Hepatology, 2023
Pulling back the curtain: The hidden functions of receptor tyrosine kinases in development.
Clark JF et al.
Current Topics in Developmental Biology, 2022
Intracellular RET signaling pathways activated by GDNF.
Kawai K et al.
Cell and Tissue Research, 2020
RET isoform-specific interaction with scaffold protein Ezrin promotes cell migration and chemotaxis in lung adenocarcinoma.
Moodley S et al.
Lung Cancer (amsterdam, Netherlands), 2020
PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential.
Yadav L et al.
Iscience, 2020
Signal Transducer and Activator of Transcription 1 Plays a Pivotal Role in RET/PTC3 Oncogene-induced Expression of Indoleamine 2,3-Dioxygenase 1.
Moretti S et al.
The Journal of Biological Chemistry, 2017
RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements.
Plaza-Menacho I et al.
Cell Reports, 2016
Mechanisms of RET signaling in cancer: current and future implications for targeted therapy.
Plaza-Menacho I et al.
Cellular Signalling, 2014
To bud or not to bud: the RET perspective in CAKUT.
Davis TK et al.
Pediatric Nephrology (berlin, Germany), 2014
Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans.
Plaza-Menacho I et al.
Molecular Cell, 2014
Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism.
Plaza-Menacho I et al.
The Journal of Biological Chemistry, 2011
Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice.
Jain S et al.
The Journal of Clinical Investigation, 2010
Cell migration by a FRS2-adaptor dependent membrane relocation of ret receptors.
Lundgren TK et al.
Journal of Cellular Biochemistry, 2008
SH2B1beta adaptor is a key enhancer of RET tyrosine kinase signaling.
Donatello S et al.
Oncogene, 2007
Deciphering adaptor specificity in GFL-dependent RET-mediated proliferation and neurite outgrowth.
Gustin JA et al.
Journal of Neurochemistry, 2007
RET ligand-induced internalization and its consequences for downstream signaling.
Richardson DS et al.
Oncogene, 2006
Interaction of SH2-Bbeta with RET is involved in signaling of GDNF-induced neurite outgrowth.
Zhang Y et al.
Journal of Cell Science, 2006
Critical and distinct roles for key RET tyrosine docking sites in renal development.
Jain S et al.
Genes & Development, 2006
Tyrosine 981, a novel ret autophosphorylation site, binds c-Src to mediate neuronal survival.
Encinas M et al.
The Journal of Biological Chemistry, 2004
Identification of RET autophosphorylation sites by mass spectrometry.
Kawamoto Y et al.
The Journal of Biological Chemistry, 2004
Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine.
Kato M et al.
Cancer Research, 2002
Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction.
Kurokawa K et al.
Oncogene, 2001
Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase.
Besset V et al.
The Journal of Biological Chemistry, 2000
Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway.
Segouffin-Cariou C et al.
The Journal of Biological Chemistry, 2000
A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins.
Asai N et al.
The Journal of Biological Chemistry, 1996
Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN2A or MEN2B mutation.
Iwashita T et al.
Oncogene, 1996