Associated Papers
CCDC6-RET fusion protein regulates Ras/MAPK signaling through the fusion- GRB2-SHC1 signal niche.
Qiu T et al.
Proceedings of the National Academy of Sciences of the United States of America, 2024
A Single RET Mutation in Hirschsprung Disease Induces Intestinal Aganglionosis Via a Dominant-Negative Mechanism.
Sunardi M et al.
Cellular and Molecular Gastroenterology and Hepatology, 2023
Pulling back the curtain: The hidden functions of receptor tyrosine kinases in development.
Clark JF et al.
Current Topics in Developmental Biology, 2022
Intracellular RET signaling pathways activated by GDNF.
Kawai K et al.
Cell and Tissue Research, 2020
Reciprocal Spatiotemporally Controlled Apoptosis Regulates Wolffian Duct Cloaca Fusion.
Hoshi M et al.
Journal of the American Society of Nephrology : Jasn, 2018
Differential recruitment of E3 ubiquitin ligase complexes regulates RET isoform internalization.
Hyndman BD et al.
Journal of Cell Science, 2017
Yap and Taz are required for Ret-dependent urinary tract morphogenesis.
Reginensi A et al.
Development (cambridge, England), 2015
To bud or not to bud: the RET perspective in CAKUT.
Davis TK et al.
Pediatric Nephrology (berlin, Germany), 2014
Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans.
Plaza-Menacho I et al.
Molecular Cell, 2014
Novel mechanisms of early upper and lower urinary tract patterning regulated by RetY1015 docking tyrosine in mice.
Hoshi M et al.
Development (cambridge, England), 2012
The Ca2+-calmodulin-dependent kinase II is activated in papillary thyroid carcinoma (PTC) and mediates cell proliferation stimulated by RET/PTC.
Rusciano MR et al.
Endocrine-related Cancer, 2010
Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis.
Lu BC et al.
Nature Genetics, 2009
Deciphering adaptor specificity in GFL-dependent RET-mediated proliferation and neurite outgrowth.
Gustin JA et al.
Journal of Neurochemistry, 2007
RET ligand-induced internalization and its consequences for downstream signaling.
Richardson DS et al.
Oncogene, 2006
Interaction of SH2-Bbeta with RET is involved in signaling of GDNF-induced neurite outgrowth.
Zhang Y et al.
Journal of Cell Science, 2006
Critical and distinct roles for key RET tyrosine docking sites in renal development.
Jain S et al.
Genes & Development, 2006
Distinct turnover of alternatively spliced isoforms of the RET kinase receptor mediated by differential recruitment of the Cbl ubiquitin ligase.
Scott RP et al.
The Journal of Biological Chemistry, 2005
The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells.
Melillo RM et al.
The Journal of Clinical Investigation, 2005
Autocrine stimulation by osteopontin plays a pivotal role in the expression of the mitogenic and invasive phenotype of RET/PTC-transformed thyroid cells.
Castellone MD et al.
Oncogene, 2004
RET/PTC-induced dedifferentiation of thyroid cells is mediated through Y1062 signaling through SHC-RAS-MAP kinase.
Knauf JA et al.
Oncogene, 2003
Protein kinase Calpha activation by RET: evidence for a negative feedback mechanism controlling RET tyrosine kinase.
Andreozzi F et al.
Oncogene, 2003
Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes.
Castellone MD et al.
Oncogene, 2003
The roles of phosphotyrosines-294, -404, and -451 in RET/PTC1-induced thyroid tumor formation.
Buckwalter TL et al.
Oncogene, 2002
Activation of RET tyrosine kinase regulates interleukin-8 production by multiple signaling pathways.
Iwahashi N et al.
Biochemical and Biophysical Research Communications, 2002
Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine.
Kato M et al.
Cancer Research, 2002
Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade.
Melillo RM et al.
Molecular and Cellular Biology, 2001
Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction.
Kurokawa K et al.
Oncogene, 2001
Cancers connected with mutations in RET proto-oncogene.
Altanerová V
Neoplasma, 2001
Tyrosines 1015 and 1062 are in vivo autophosphorylation sites in ret and ret-derived oncoproteins.
Salvatore D et al.
The Journal of Clinical Endocrinology and Metabolism, 2000
Two distinct mutations of the RET receptor causing Hirschsprung's disease impair the binding of signalling effectors to a multifunctional docking site.
Geneste O et al.
Human Molecular Genetics, 1999
The role of the ret proto-oncogene in human disease.
Takahashi M
Nagoya Journal of Medical Science, 1997
RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2.
Lorenzo MJ et al.
Oncogene, 1997
A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins.
Asai N et al.
The Journal of Biological Chemistry, 1996
Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities.
Liu X et al.
The Journal of Biological Chemistry, 1996
Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN2A or MEN2B mutation.
Iwashita T et al.
Oncogene, 1996
Detection of the PTC/retTPC oncogene in human thyroid cancers.
Jhiang SM et al.
Oncogene, 1992