Associated Papers
Regulation of the Rheb GTPase via GATOR1 Complex.
Prabhakar A et al.
Biorxiv : the Preprint Server for Biology, 2025
HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis.
Ikeda T et al.
Cell Reports, 2025
The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation.
Yao Y et al.
Cell Reports, 2025
Rheb regulates nuclear mTORC1 activity independent of farnesylation.
Zhong Y et al.
Cell Chemical Biology, 2022
CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function.
Sethna S et al.
Nature Communications, 2021
NMR analysis of the backbone dynamics of the small GTPase Rheb and its interaction with the regulatory protein FKBP38.
De Cicco M et al.
Febs Letters, 2018
MCRS1 binds and couples Rheb to amino acid-dependent mTORC1 activation.
Fawal MA et al.
Developmental Cell, 2015
Recent progress in the study of the Rheb family GTPases.
Heard JJ et al.
Cellular Signalling, 2014
Rheb GTPase regulates β-secretase levels and amyloid β generation.
Shahani N et al.
The Journal of Biological Chemistry, 2014
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