Associated Papers
Regulation of the Rheb GTPase via GATOR1 Complex.
Prabhakar A et al.
Biorxiv : the Preprint Server for Biology, 2025
The mTOR pathway controls phosphorylation of BRAF at T401.
Christen D et al.
Cell Communication and Signaling : Ccs, 2024
IL-37d suppresses Rheb-mTORC1 axis independently of TCS2 to alleviate alcoholic liver disease.
Chen N et al.
Communications Biology, 2024
Development of a versatile HPLC-based method to evaluate the activation status of small GTPases.
Araki M et al.
The Journal of Biological Chemistry, 2021
CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function.
Sethna S et al.
Nature Communications, 2021
TSC-insensitive Rheb mutations induce oncogenic transformation through a combination of constitutively active mTORC1 signalling and proteome remodelling.
Xie J et al.
Cellular and Molecular Life Sciences : Cmls, 2021
Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response.
Wang W et al.
Nature Communications, 2021
Expression of transgenes enriched in rare codons is enhanced by the MAPK pathway.
Peterson J et al.
Scientific Reports, 2020
Iron overload inhibits late stage autophagic flux leading to insulin resistance.
Jahng JWS et al.
Embo Reports, 2019
Contribution of Altered Endocannabinoid System to Overactive mTORC1 Signaling in Focal Cortical Dysplasia.
García-Rincón D et al.
Frontiers in Pharmacology, 2018
Notch transactivates Rheb to maintain the multipotency of TSC-null cells.
Cho JH et al.
Nature Communications, 2017
Inhibition of MAPK pathway is essential for suppressing Rheb-Y35N driven tumor growth.
Wang Y et al.
Oncogene, 2017
TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy.
García-Aguilar A et al.
Biochimica Et Biophysica Acta, 2016
MARCH2 regulates autophagy by promoting CFTR ubiquitination and degradation and PIK3CA-AKT-MTOR signaling.
Xia D et al.
Autophagy, 2016
Gankyrin activates mTORC1 signaling by accelerating TSC2 degradation in colorectal cancer.
Qin X et al.
Cancer Letters, 2016
PRKCI negatively regulates autophagy via PIK3CA/AKT-MTOR signaling.
Qu L et al.
Biochemical and Biophysical Research Communications, 2016
MCRS1 binds and couples Rheb to amino acid-dependent mTORC1 activation.
Fawal MA et al.
Developmental Cell, 2015
Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway.
Wei FZ et al.
Autophagy, 2015
Recent progress in the study of the Rheb family GTPases.
Heard JJ et al.
Cellular Signalling, 2014
Rheb GTPase regulates β-secretase levels and amyloid β generation.
Shahani N et al.
The Journal of Biological Chemistry, 2014
Novel role for SHP-2 in nutrient-responsive control of S6 kinase 1 signaling.
Mercan F et al.
Molecular and Cellular Biology, 2013
Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling.
Hanker AB et al.
Oncogene, 2010
Tumorigenic activity and therapeutic inhibition of Rheb GTPase.
Mavrakis KJ et al.
Genes & Development, 2008
Biochemical and biological characterization of tumor-associated mutations of p110alpha.
Denley A et al.
Methods in Enzymology, 2008
Characterization of the Rheb-mTOR signaling pathway in mammalian cells: constitutive active mutants of Rheb and mTOR.
Sato T et al.
Methods in Enzymology, 2008
Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization.
Karbowniczek M et al.
The Journal of Biological Chemistry, 2006
Structural basis for the unique biological function of small GTPase RHEB.
Yu Y et al.
The Journal of Biological Chemistry, 2005
Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.
Karbowniczek M et al.
The Journal of Biological Chemistry, 2004
TSC2: filling the GAP in the mTOR signaling pathway.
Li Y et al.
Trends in Biochemical Sciences, 2004