Associated Papers
Constitutively active rhodopsin and retinal disease.
Park PS
Advances in Pharmacology (san Diego, Calif.), 2014
Alterations in the photoactivation pathway of rhodopsin mutants associated with retinitis pigmentosa.
Bosch-Presegué L et al.
The Febs Journal, 2011
Lipid protein interactions couple protonation to conformation in a conserved cytosolic domain of G protein-coupled receptors.
Madathil S et al.
The Journal of Biological Chemistry, 2009
Crystal structure of opsin in its G-protein-interacting conformation.
Scheerer P et al.
Nature, 2008
Molecular dynamics simulations of rhodopsin point mutants at the cytoplasmic side of helices 3 and 6.
Cordomí A et al.
Journal of Biomolecular Structure & Dynamics, 2008
Rhodopsin and 9-demethyl-retinal analog: effect of a partial agonist on displacement of transmembrane helix 6 in class A G protein-coupled receptors.
Knierim B et al.
The Journal of Biological Chemistry, 2008
G protein-coupled receptors disrupted in human genetic disease.
Thompson MD et al.
Methods in Molecular Biology (clifton, N.j.), 2008
Engineering a "steric doorstop" in rhodopsin: converting an inverse agonist to an agonist.
McKee TD et al.
Biochemistry, 2007
Critical role of electrostatic interactions of amino acids at the cytoplasmic region of helices 3 and 6 in rhodopsin conformational properties and activation.
Ramon E et al.
The Journal of Biological Chemistry, 2007
Vertebrate opsins belonging to different classes vary in constitutively active properties resulting from salt-bridge mutations.
Nickle B et al.
Biochemistry, 2006
Partial agonism in a G Protein-coupled receptor: role of the retinal ring structure in rhodopsin activation.
Bartl FJ et al.
The Journal of Biological Chemistry, 2005
The spectrum of human rhodopsin disease mutations through the lens of interspecific variation.
Briscoe AD et al.
Gene, 2004
Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation.
Fritze O et al.
Proceedings of the National Academy of Sciences of the United States of America, 2003
Transducin-dependent protonation of glutamic acid 134 in rhodopsin.
Fahmy K et al.
Biochemistry, 2000
Theoretical study on mutation-induced activation of the luteinizing hormone receptor.
Fanelli F
Journal of Molecular Biology, 2000
Mutation of the fourth cytoplasmic loop of rhodopsin affects binding of transducin and peptides derived from the carboxyl-terminal sequences of transducin alpha and gamma subunits.
Ernst OP et al.
The Journal of Biological Chemistry, 2000
Development of stable cell lines expressing high levels of point mutants of human opsin for biochemical and biophysical studies.
Sullivan JM et al.
Methods in Enzymology, 2000
Electrical approach to study rhodopsin activation in single cells with early receptor current assay.
Sullivan JM et al.
Methods in Enzymology, 2000
Constitutive activation of opsin by mutation of methionine 257 on transmembrane helix 6.
Han M et al.
Biochemistry, 1998
Modulation of GDP release from transducin by the conserved Glu134-Arg135 sequence in rhodopsin.
Acharya S et al.
The Journal of Biological Chemistry, 1996
Rhodopsin activation: effects on the metarhodopsin I-metarhodopsin II equilibrium of neutralization or introduction of charged amino acids within putative transmembrane segments.
Weitz CJ et al.
Biochemistry, 1993
Regulation of the rhodopsin-transducin interaction by a highly conserved carboxylic acid group.
Fahmy K et al.
Biochemistry, 1993
Constitutive activation of opsin: influence of charge at position 134 and size at position 296.
Cohen GB et al.
Biochemistry, 1993
Structure and function in rhodopsin. Studies of the interaction between the rhodopsin cytoplasmic domain and transducin.
Franke RR et al.
The Journal of Biological Chemistry, 1992
Determinants of visual pigment absorbance: identification of the retinylidene Schiff's base counterion in bovine rhodopsin.
Nathans J
Biochemistry, 1990
Effect of carboxyl mutations on functional properties of bovine rhodopsin.
DeCaluwé GL et al.
Biophysical Chemistry, 0