Varaico: Literature-Extracted Genetic Variants

Gene:RHO
Variant:p.I307N
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RHO

NM_000539.3:p.I307N

Associated Papers

Preventing light-induced toxicity in a new mouse model of sector retinitis pigmentosa caused by Rhodopsin M39R variant.

Guarascio R et al.

Cell Death Discovery, 2025

Insights into rhodopsin molecular evolution from mice with "humanized" Phe-88 to Leu substitution.

Wang F et al.

Research Square, 2025

Small-Molecule Ligands of Rhodopsin and Their Therapeutic Potential in Retina Degeneration.

Pashandi Z et al.

International Journal of Molecular Sciences, 2025

New insights into the molecular mechanism of rhodopsin retinitis pigmentosa from the biochemical and functional characterization of G90V, Y102H and I307N mutations.

Herrera-Hernández MG et al.

Cellular and Molecular Life Sciences : Cmls, 2022

Nutraceutical Molecules Slow Down Retinal Degeneration, in Tvrm4 Mice a Model of Retinitis Pigmentosa, by Genetic Modulation of Anti-oxidant Pathway.

Piano I et al.

Frontiers in Neuroscience, 2022

Retinal Pigment Epithelium Remodeling in Mouse Models of Retinitis Pigmentosa.

Napoli D et al.

International Journal of Molecular Sciences, 2021

Effect of Sodium Valproate on the Conformational Stability of the Visual G Protein-Coupled Receptor Rhodopsin.

Razzaghi N et al.

Molecules (basel, Switzerland), 2021

Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors.

Ribeiro J et al.

Cell Reports, 2021

33882303 (PubMed )
Supplement: mmc2.pdf

Sectoral activation of glia in an inducible mouse model of autosomal dominant retinitis pigmentosa.

Massengill MT et al.

Scientific Reports, 2020

Inner retinal preservation in the photoinducible I307N rhodopsin mutant mouse, a model of autosomal dominant retinitis pigmentosa.

Stefanov A et al.

The Journal of Comparative Neurology, 2020

Myriocin Effect on Tvrm4 Retina, an Autosomal Dominant Pattern of Retinitis Pigmentosa.

Piano I et al.

Frontiers in Neuroscience, 2020

Wheel running exercise protects against retinal degeneration in the I307N rhodopsin mouse model of inducible autosomal dominant retinitis pigmentosa.

Zhang X et al.

Molecular Vision, 2019

Clinically Relevant Outcome Measures for the I307N Rhodopsin Mouse: A Model of Inducible Autosomal Dominant Retinitis Pigmentosa.

Massengill MT et al.

Investigative Ophthalmology & Visual Science, 2018

Pattern of retinal morphological and functional decay in a light-inducible, rhodopsin mutant mouse.

Gargini C et al.

Scientific Reports, 2017

Mouse models of human ocular disease for translational research.

Krebs MP et al.

Plos One, 2017

Assessment of visual function and retinal structure following acute light exposure in the light sensitive T4R rhodopsin mutant dog.

Iwabe S et al.

Experimental Eye Research, 2016

Gene therapy to rescue retinal degeneration caused by mutations in rhodopsin.

Rossmiller BP et al.

Methods in Molecular Biology (clifton, N.j.), 2015

Gene augmentation for adRP mutations in RHO.

Lewin AS et al.

Cold Spring Harbor Perspectives in Medicine, 2014

Gene therapy in animal models of autosomal dominant retinitis pigmentosa.

Rossmiller B et al.

Molecular Vision, 2012

Mutations of the opsin gene (Y102H and I307N) lead to light-induced degeneration of photoreceptors and constitutive activation of phototransduction in mice.

Budzynski E et al.

The Journal of Biological Chemistry, 2010

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."