Associated Papers
A CRISPR activation screen reveals a cilia disassembly pathway mutated in focal cortical dysplasia.
Elliott SD et al.
Science Advances, 2025
Binding of RHOA G17V to p300 enhances its HAT activity: a new mechanism of epigenetic deregulation in TFH lymphoma.
Vallois D et al.
Blood Advances, 2025
A postzygotic GNA13 variant upregulates the RHOA/ROCK pathway and alters melanocyte function in a mosaic skin hypopigmentation syndrome.
El Masri R et al.
Nature Communications, 2025
The mevalonate pathway contributes to breast primary tumorigenesis and lung metastasis.
Conde J et al.
Molecular Oncology, 2025
Function of a complex of p-Y42 RhoA GTPase and pyruvate kinase M2 in EGF signaling pathway in glioma cells.
Lee YB et al.
Journal of Neurochemistry, 2025
Tumor-derived RHOA mutants interact with effectors in the GDP-bound state.
Lin Y et al.
Nature Communications, 2024
RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling.
Schaefer A et al.
Science Signaling, 2023
Wavelet coherence phase analysis decodes the universal switching mechanism of Ras GTPase superfamily.
Motiwala Z et al.
Iscience, 2023
MICAL1 activation by PAK1 mediates actin filament disassembly.
McGarry DJ et al.
Cell Reports, 2022
Active RhoA Exerts an Inhibitory Effect on the Homeostasis and Angiogenic Capacity of Human Endothelial Cells.
Hauke M et al.
Journal of the American Heart Association, 2022
Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis.
Robles-Valero J et al.
The Embo Journal, 2021
Structure of an inactive conformation of GTP-bound RhoA GTPase.
Lin Y et al.
Structure (london, England : 1993), 2021
RAS and RHO family GTPase mutations in cancer: twin sons of different mothers?
Hodge RG et al.
Critical Reviews in Biochemistry and Molecular Biology, 2020
Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer.
Zhang H et al.
Cancer Discovery, 2020
Selection and Characterization of a Nanobody Biosensor of GTP-Bound RHO Activities.
Keller L et al.
Antibodies (basel, Switzerland), 2019
Loss of the BCR-FGFR1 GEF Domain Suppresses RHOA Activation and Enhances B-Lymphomagenesis in Mice.
Hu T et al.
Cancer Research, 2019
The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.
O'Loughlin T et al.
Embo Reports, 2018
RHO binding to FAM65A regulates Golgi reorientation during cell migration.
Mardakheh FK et al.
Journal of Cell Science, 2016
Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS.
Amin E et al.
The Journal of Biological Chemistry, 2016
Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells.
O'Hayre M et al.
Oncogene, 2016
Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas.
Palomero T et al.
Nature Genetics, 2014
RHOA-FAK is a required signaling axis for the maintenance of KRAS-driven lung adenocarcinomas.
Konstantinidou G et al.
Cancer Discovery, 2013
Identification of the integrin β3 L718P mutation in a pedigree with autosomal dominant thrombocytopenia with anisocytosis.
Kobayashi Y et al.
British Journal of Haematology, 2013
The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer.
Medina PP et al.
Human Molecular Genetics, 2009