Varaico: Literature-Extracted Genetic Variants

Gene:RHOA
Variant:p.L57V
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RHOA

NM_001664.4:p.L57V

Associated Papers

Comprehensive Evaluation of a 1021-Gene Panel in FFPE and Liquid Biopsy for Analytical and Clinical Use.

Meintani A et al.

International Journal of Molecular Sciences, 2025

40649709 (PubMed )
Supplement: ijms-26-05930-s001.zip › Supplementary_Table_2_and_Figure_S1.xlsx › Table_S3

Comprehensive mapping elucidates high risk genotypes in primary metastatic breast cancer.

Berg T et al.

Neoplasia (new York, N.y.), 2025

40121945 (PubMed )
Supplement: mmc5.xlsx › Ark1

Tumor-derived RHOA mutants interact with effectors in the GDP-bound state.

Lin Y et al.

Nature Communications, 2024

Genomic and Pathologic Profiling of Very Well-Differentiated Gastric Adenocarcinoma of Intestinal Type: A Study With Emphasis on Diffuse-Type Transformation.

Rokutan H et al.

The American Journal of Surgical Pathology, 2024

RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling.

Schaefer A et al.

Science Signaling, 2023

RHOA drivers take alternate routes in gastric cancer.

Benton D et al.

Science Signaling, 2023

Multiancestry genomic and transcriptomic analysis of gastric cancer.

Totoki Y et al.

Nature Genetics, 2023

Whole-Exome Sequencing Among Chinese Patients With Hereditary Diffuse Gastric Cancer.

Liu ZX et al.

Jama Network Open, 2022

36484990 (PubMed )
Supplement: jamanetwopen-e2245836-s002.xlsx › Table_S5

ARHGAP-RhoA signaling provokes homotypic adhesion-triggered cell death of metastasized diffuse-type gastric cancer.

Komatsu M et al.

Oncogene, 2022

Mutational landscape of marginal zone B-cell lymphomas of various origin: organotypic alterations and diagnostic potential for assignment of organ origin.

Vela V et al.

Virchows Archiv : an International Journal of Pathology, 2022

34494161 (PubMed )
Supplement: 428_2021_3186_MOESM21_ESM.xlsx › Supplementary_Table_8

Spatially interacting phosphorylation sites and mutations in cancer.

Huang KL et al.

Nature Communications, 2021

33875650 (PubMed )
Supplement: 41467_2021_22481_MOESM4_ESM.xlsx › TableS1.HybridClusters

Distinct genomic profile in h. pylori-associated gastric cancer.

Zhang X et al.

Cancer Medicine, 2021

33751865 (PubMed )
Supplement: CAM4-10-2461-s001.xlsx › somatic_muts.gastric_samples.le

The predicting role of circulating tumor DNA landscape in gastric cancer patients treated with immune checkpoint inhibitors.

Jin Y et al.

Molecular Cancer, 2020

Somatic Evolution in Non-neoplastic IBD-Affected Colon.

Olafsson S et al.

Cell, 2020

32697969 (PubMed )
Supplement: mmc4.xlsx › A__TCGA_hotspots

RAS and RHO family GTPase mutations in cancer: twin sons of different mothers?

Hodge RG et al.

Critical Reviews in Biochemistry and Molecular Biology, 2020

Gene mutations distinguishing gastric from colorectal and esophageal adenocarcinomas.

Hoang T et al.

Journal of Gastrointestinal Oncology, 2020

Identification of candidates for driver oncogenes in scirrhous-type gastric cancer cell lines.

Sai E et al.

Cancer Science, 2019

RHOA mutations and CLDN18-ARHGAP fusions in intestinal-type adenocarcinoma with anastomosing glands of the stomach.

Hashimoto T et al.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2019

Analysis of error profiles in deep next-generation sequencing data.

Ma X et al.

Genome Biology, 2019

30867008 (PubMed )
Supplement: 13059_2019_1659_MOESM1_ESM.xlsx › S3_b

DGC-specific RHOA mutations maintained cancer cell survival and promoted cell migration via ROCK inactivation.

Nishizawa T et al.

Oncotarget, 2018

Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers.

Cho SY et al.

Gastroenterology, 2017

Variegated RHOA mutations in human cancers.

Kataoka K et al.

Experimental Hematology, 2016

The genetic landscape of dural marginal zone lymphomas.

Ganapathi KA et al.

Oncotarget, 2016

27248180 (PubMed )
Supplement: oncotarget-07-43052-s003.xlsx › Supp_Table_3

RHOA mutation may be associated with diffuse-type gastric cancer progression, but is it gain or loss?

Maeda M et al.

Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2016

Genetic alterations and their clinical implications in gastric cancer peritoneal carcinomatosis revealed by whole-exome sequencing of malignant ascites.

Lim B et al.

Oncotarget, 2016

Clinicopathological characteristics of RHOA mutations in a Central European gastric cancer cohort.

Röcken C et al.

Journal of Clinical Pathology, 2016

Gene mutations in gastric cancer: a review of recent next-generation sequencing studies.

Lin Y et al.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine, 2015

Genomic landscape and genetic heterogeneity in gastric adenocarcinoma revealed by whole-genome sequencing.

Wong SS et al.

Nature Communications, 2014

Comprehensive molecular characterization of gastric adenocarcinoma.

Unknown Author

Nature, 2014

RhoA mutations identified in diffuse gastric cancer.

Zhou J et al.

Cancer Cell, 2014

Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.

Wang K et al.

Nature Genetics, 2014

Genomics Study of Gastric Cancer and Its Molecular Subtypes.

Yuen ST et al.

Advances in Experimental Medicine and Biology, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."