Associated Papers
Translating Gastric Cancer Genomics into Targeted Therapy: Mechanistic Insights from Animal Models and Patient-Derived Systems.
Shyu RY et al.
Cells, 2026
Ancestry-dependent patterns of somatic mosaicism and clonal hematopoiesis mutations in over 125,000 individuals reveal distinct cancer associations.
Colin-Leitzinger C et al.
Human Genomics, 2025
MRD4U: A path to development for personalized liquid biopsy for children with central nervous system tumors.
Miller AR et al.
Bmc Cancer, 2025
Distinct characteristics of lymphoid and myeloid clonal hematopoiesis in World Trade Center first responders.
Esai Selvan M et al.
Medrxiv : the Preprint Server for Health Sciences, 2025
Comprehensive Evaluation of a 1021-Gene Panel in FFPE and Liquid Biopsy for Analytical and Clinical Use.
Meintani A et al.
International Journal of Molecular Sciences, 2025
Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes.
Hiitola E et al.
Science Advances, 2025
Peripheral blood somatic mosaicism and clonal hematopoiesis across ancestry backgrounds.
Colin-Leitzinger C et al.
Medrxiv : the Preprint Server for Health Sciences, 2025
Mapping variant effects on anti-tumor hallmarks of primary human T cells with base-editing screens.
Walsh ZH et al.
Nature Biotechnology, 2025
The theory of massively repeated evolution and full identifications of cancer-driving nucleotides (CDNs).
Zhang L et al.
Elife, 2024
GLI1 confers resistance to PARP inhibitors by activating the DNA damage repair pathway.
Ikeuchi H et al.
Oncogene, 2024
Tumor-derived RHOA mutants interact with effectors in the GDP-bound state.
Lin Y et al.
Nature Communications, 2024
Efficacy of immunotherapy in ARID1A-mutant solid tumors: a single-center retrospective study.
Zhou H et al.
Discover Oncology, 2024
Genomic and Pathologic Profiling of Very Well-Differentiated Gastric Adenocarcinoma of Intestinal Type: A Study With Emphasis on Diffuse-Type Transformation.
Rokutan H et al.
The American Journal of Surgical Pathology, 2024
Combining germline, tissue and liquid biopsy analysis by comprehensive genomic profiling to improve the yield of actionable variants in a real-world cancer cohort.
Vanni I et al.
Journal of Translational Medicine, 2024
Somatic mutations that affect early genetic progression and immune microenvironment in gastric carcinoma.
Li X et al.
Pathology, Research and Practice, 2024
E-cadherin loss drives diffuse-type gastric tumorigenesis via EZH2-mediated reprogramming.
Zou G et al.
The Journal of Experimental Medicine, 2024
RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling.
Schaefer A et al.
Science Signaling, 2023
RHOA drivers take alternate routes in gastric cancer.
Benton D et al.
Science Signaling, 2023
Mechanotransduction in response to ECM stiffening impairs cGAS immune signaling in tumor cells.
Liu Y et al.
Cell Reports, 2023
CDH1 loss promotes diffuse-type gastric cancer tumorigenesis via epigenetic reprogramming and immune evasion.
Zou G et al.
Biorxiv : the Preprint Server for Biology, 2023
The Mutational, Prognostic, and Therapeutic Landscape of Neuroendocrine Neoplasms.
Liu M et al.
The Oncologist, 2023
Molecular Landscape and Association With Crohn Disease of Poorly Cohesive Carcinomas of the Nonampullary Small Bowel.
Tedaldi G et al.
American Journal of Clinical Pathology, 2023
Multiancestry genomic and transcriptomic analysis of gastric cancer.
Totoki Y et al.
Nature Genetics, 2023
Sensitive Detection of Cell-Free Tumour DNA Using Optimised Targeted Sequencing Can Predict Prognosis in Gastro-Oesophageal Cancer.
Wallander K et al.
Cancers, 2023
Whole-Exome Sequencing Among Chinese Patients With Hereditary Diffuse Gastric Cancer.
Liu ZX et al.
Jama Network Open, 2022
ARHGAP-RhoA signaling provokes homotypic adhesion-triggered cell death of metastasized diffuse-type gastric cancer.
Komatsu M et al.
Oncogene, 2022
Functional and biological heterogeneity of KRASQ61 mutations.
Huynh MV et al.
Science Signaling, 2022
RHOA takes the RHOad less traveled to cancer.
Schaefer A et al.
Trends in Cancer, 2022
Mapping the genomic diaspora of gastric cancer.
Yeoh KG et al.
Nature Reviews. Cancer, 2022
Rho GTPase signaling in cancer progression and dissemination.
Crosas-Molist E et al.
Physiological Reviews, 2022
Advantages and Limitations of Monitoring Circulating Tumor DNA Levels to Predict the Prognosis of Patients Diagnosed With Gastric Cancer.
He W et al.
Biomarker Insights, 2022
Analysis of RHOA mutations and their significance in the proliferation and transcriptome of digestive tract cancer cells.
Ikari N et al.
Oncology Letters, 2021
Distinct genomic profile in h. pylori-associated gastric cancer.
Zhang X et al.
Cancer Medicine, 2021
Transitioning the Molecular Tumor Board from Proof of Concept to Clinical Routine: A German Single-Center Analysis.
Hoefflin R et al.
Cancers, 2021
Mutational drivers of cancer cell migration and invasion.
Novikov NM et al.
British Journal of Cancer, 2021
RHOA mutation in follicular T-cell lymphoma: Clinicopathological analysis of 16 cases.
Miyoshi H et al.
Pathology International, 2020
Somatic Evolution in Non-neoplastic IBD-Affected Colon.
Olafsson S et al.
Cell, 2020
RAS and RHO family GTPase mutations in cancer: twin sons of different mothers?
Hodge RG et al.
Critical Reviews in Biochemistry and Molecular Biology, 2020
A risk-associated Active transcriptome phenotype expressed by histologically normal human breast tissue and linked to a pro-tumorigenic adipocyte population.
Kang T et al.
Breast Cancer Research : Bcr, 2020
Hormones Secretion and Rho GTPases in Neuroendocrine Tumors.
Streit L et al.
Cancers, 2020
Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer.
Zhang H et al.
Cancer Discovery, 2020
Gene mutations distinguishing gastric from colorectal and esophageal adenocarcinomas.
Hoang T et al.
Journal of Gastrointestinal Oncology, 2020
Diversity spectrum analysis identifies mutation-specific effects of cancer driver genes.
Dong X et al.
Communications Biology, 2020