Associated Papers
Parkinson's disease mutant Miro1 causes mitochondrial dysfunction and dopaminergic neuron loss.
Chemla A et al.
Brain : a Journal of Neurology, 2025
MIRO1 controls energy production and proliferation of vascular smooth muscle cells.
Qian L et al.
Biorxiv : the Preprint Server for Biology, 2025
MIRO1 mutation leads to metabolic maladaptation resulting in Parkinson's disease-associated dopaminergic neuron loss.
Zagare A et al.
Npj Systems Biology and Applications, 2025
Deciphering shared molecular dysregulation across Parkinson's disease variants using a multi-modal network-based data integration and analysis.
Zagare A et al.
Npj Parkinson's Disease, 2025
Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson's disease patients carrying the heterozygous mutations c.815G > A (p.R272Q) or c.1348C > T (p.R450C) in the RHOT1 gene encoding Miro1.
Chemla A et al.
Stem Cell Research, 2023
Miro1 R272Q disrupts mitochondrial calcium handling and neurotransmitter uptake in dopaminergic neurons.
Schwarz L et al.
Frontiers in Molecular Neuroscience, 2022
Generation of R272Q, S156A and K572R RHOT1/Miro1 point mutations in iPSCs from a healthy individual using FACS-assisted CRISPR/Cas9 genome editing.
Schwarz L et al.
Stem Cell Research, 2021
The role of RHOT1 and RHOT2 genetic variation on Parkinson disease risk and onset.
Periñán MT et al.
Neurobiology of Aging, 2021
Impaired mitochondrial-endoplasmic reticulum interaction and mitophagy in Miro1-mutant neurons in Parkinson's disease.
Berenguer-Escuder C et al.
Human Molecular Genetics, 2020
The Emerging Role of RHOT1/Miro1 in the Pathogenesis of Parkinson's Disease.
Grossmann D et al.
Frontiers in Neurology, 2020
Variants in Miro1 Cause Alterations of ER-Mitochondria Contact Sites in Fibroblasts from Parkinson's Disease Patients.
Berenguer-Escuder C et al.
Journal of Clinical Medicine, 2019
Mutations in RHOT1 Disrupt Endoplasmic Reticulum-Mitochondria Contact Sites Interfering with Calcium Homeostasis and Mitochondrial Dynamics in Parkinson's Disease.
Grossmann D et al.
Antioxidants & Redox Signaling, 2019
Select a paper to view details