Varaico: Literature-Extracted Genetic Variants

Gene:RIGI
Variant:p.T55I
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RIGI

NM_014314.4:p.T55I

Associated Papers

Identification of Characteristic Genomic Markers in Human Hepatoma HuH-7 and Huh7.5.1-8 Cell Lines.

Kawamoto M et al.

Frontiers in Genetics, 2020

Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.

Uchikawa E et al.

Molecular Cell, 2016

27203181 (PubMed )
Supplement: mmc1.pdf

Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5.

Louber J et al.

Bmc Biology, 2015

Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor.

Zhu J et al.

Immunity, 2014

Activation of duck RIG-I by TRIM25 is independent of anchored ubiquitin.

Miranzo-Navarro D et al.

Plos One, 2014

Ubiquitin regulates caspase recruitment domain-mediated signaling by nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2.

Ver Heul AM et al.

The Journal of Biological Chemistry, 2013

A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses.

Oshiumi H et al.

Plos Pathogens, 2013

Structure and dynamics of the second CARD of human RIG-I provide mechanistic insights into regulation of RIG-I activation.

Ferrage F et al.

Structure (london, England : 1993), 2012

A cell-based assay for RNA synthesis by the HCV polymerase reveals new insights on mechanism of polymerase inhibitors and modulation by NS5A.

Ranjith-Kumar CT et al.

Plos One, 2011

Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity.

Zeng W et al.

Cell, 2010

Study of human RIG-I polymorphisms identifies two variants with an opposite impact on the antiviral immune response.

Pothlichet J et al.

Plos One, 2009

Identification of loss of function mutations in human genes encoding RIG-I and MDA5: implications for resistance to type I diabetes.

Shigemoto T et al.

The Journal of Biological Chemistry, 2009

TIR, CARD and PYRIN: three domains for an antimicrobial triad.

Werts C et al.

Cell Death and Differentiation, 2006

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."