Associated Papers
The landscape of Parkin variants reveals pathogenic mechanisms and therapeutic targets in Parkinson's disease.
Yi W et al.
Human Molecular Genetics, 2019
Alterations in the E3 ligases Parkin and CHIP result in unique metabolic signaling defects and mitochondrial quality control issues.
Lizama BN et al.
Neurochemistry International, 2018
Impact of altered phosphorylation on loss of function of juvenile Parkinsonism-associated genetic variants of the E3 ligase parkin.
Aguirre JD et al.
The Journal of Biological Chemistry, 2018
Structure of the human Parkin ligase domain in an autoinhibited state.
Wauer T et al.
The Embo Journal, 2013
23727886 (PubMed )
Supplement: emboj2013125s1.pdf
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding.
Lazarou M et al.
The Journal of Cell Biology, 2013
Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity.
Hampe C et al.
Human Molecular Genetics, 2006
How does parkin ligate ubiquitin to Parkinson's disease?
Kahle PJ et al.
Embo Reports, 2004
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