Associated Papers
Proteome-Wide Analysis of Functional Phosphosites in the FGFR Family of Proteins: Insights from Large-Scale Phosphoproteomic Analysis.
Palollathil A et al.
Proteomes, 2026
Loss of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosis.
Nemade H et al.
Cell Death & Disease, 2026
Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammatory mediators and late-onset Alzheimer's disease risk factors.
Xie X et al.
Immunity, 2026
Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome.
Narendra VK et al.
Nature, 2026
Discriminating activating, deactivating and resistance variants in protein kinases.
Singh G et al.
Genome Medicine, 2025
ATR-mediated phosphorylation of RIPK1 inhibits DNA damage-induced necroptosis.
Shi SN et al.
Biochemical Pharmacology, 2025
Pyrin inflammasome-driven erosive arthritis caused by unprenylated RHO GTPase signaling.
Akula MK et al.
Embo Molecular Medicine, 2025
RIPK1 S213E mutant suppresses RIPK1-dependent cell death by preventing interactions with RIPK3 and CASP8.
Nan N et al.
Cell Death Discovery, 2025
Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance.
Zhang B et al.
Proceedings of the National Academy of Sciences of the United States of America, 2025
TBK1-associated adapters TANK and AZI2 protect mice against TNF-induced cell death and severe autoinflammatory diseases.
Ujevic A et al.
Nature Communications, 2024
N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation.
Gitlin AD et al.
Immunity, 2024
Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1.
Yang Y et al.
Nature Cell Biology, 2024
RIPK1 activation in Mecp2-deficient microglia promotes inflammation and glutamate release in RTT.
Cao Z et al.
Proceedings of the National Academy of Sciences of the United States of America, 2024
cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation.
Schorn F et al.
The Embo Journal, 2023
UDP-glucuronate metabolism controls RIPK1-driven liver damage in nonalcoholic steatohepatitis.
Zhang T et al.
Nature Communications, 2023
RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8.
Imanishi T et al.
Science Advances, 2023
PRMT5-mediated regulatory arginine methylation of RIPK3.
Chauhan C et al.
Cell Death Discovery, 2023
Autoimmune and autoinflammatory manifestations in inborn errors of immunity.
Kačar M et al.
Current Opinion in Allergy and Clinical Immunology, 2022
Ubiquitin-binding domain in ABIN1 is critical for regulating cell death and inflammation during development.
Li M et al.
Cell Death and Differentiation, 2022
Caspase-8 Blocks Receptor-Interacting Protein Kinase-1 Kinase-Independent Necroptosis during Embryogenesis.
Zhang H et al.
Immunohorizons, 2022
TAB2 deficiency induces dilated cardiomyopathy by promoting RIPK1-dependent apoptosis and necroptosis.
Yin H et al.
The Journal of Clinical Investigation, 2022
Expression of Ripk1 and DAM genes correlates with severity and progression of Krabbe disease.
Cachón-González MB et al.
Human Molecular Genetics, 2021
OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity.
Hoste E et al.
Nature Communications, 2021
OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice.
Schünke H et al.
Nature Communications, 2021
NEK1-mediated retromer trafficking promotes blood-brain barrier integrity by regulating glucose metabolism and RIPK1 activation.
Wang H et al.
Nature Communications, 2021
Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS.
Dominguez S et al.
Cell Death and Differentiation, 2021
RIPK1-Associated Inborn Errors of Innate Immunity.
Zhang J et al.
Frontiers in Immunology, 2021
Reduction of mNAT1/hNAT2 Contributes to Cerebral Endothelial Necroptosis and Aβ Accumulation in Alzheimer's Disease.
Zou C et al.
Cell Reports, 2020
OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis.
Verboom L et al.
Cell Reports, 2020
A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1.
Tao P et al.
Nature, 2020
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease.
Lalaoui N et al.
Nature, 2020
A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms.
Priem D et al.
Cell Death & Disease, 2019
ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner.
Su Z et al.
Cell Death and Differentiation, 2019
A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain.
Polykratis A et al.
Nature Cell Biology, 2019