Varaico: Literature-Extracted Genetic Variants

Gene:RIT1
Variant:p.R122L
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RIT1

NM_006912.6:p.R122L

Associated Papers

Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state.

Rominger MC et al.

Cell Reports, 2025

41004338 (PubMed )
Supplement: NIHMS2120069-supplement-2.xlsx › A_-_AACR_GENIE_v17

RIT1 Drives Oncogenic Transformation and Is an Actionable Target in Lung Adenocarcinoma.

Mozzarelli AM et al.

Cancer Research, 2025

Noonan Syndrome: Relation of Genotype to Cardiovascular Phenotype-A Multi-Center Retrospective Study.

Ilic N et al.

Genes, 2024

39596663 (PubMed )
Supplement: genes-15-01463-s001.zip › genes-3253345-supplementary.xlsx › Table_S1_Key_Genetic_Features__

Cell Painting predicts impact of lung cancer variants.

Caicedo JC et al.

Molecular Biology of the Cell, 2022

The blended phenotype of a germline RIT1 and a mosaic PIK3CA variant.

Berland S et al.

Cold Spring Harbor Molecular Case Studies, 2021

High-throughput Phenotyping of Lung Cancer Somatic Mutations.

Berger AH et al.

Cancer Cell, 2016

Functionally Assessing Candidate Drivers Advances Precision Cancer Medicine.

Scott KL et al.

Cancer Cell, 2016

Spectrum of mutations and genotype-phenotype analysis in Noonan syndrome patients with RIT1 mutations.

Yaoita M et al.

Human Genetics, 2016

Oncogenic RIT1 mutations in lung adenocarcinoma.

Berger AH et al.

Oncogene, 2014

Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations.

Kiel C et al.

Molecular Systems Biology, 2014

24803665 (PubMed )
Supplement: MSB-10-5-727-s13.xls › energies
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."