Varaico: Literature-Extracted Genetic Variants

Gene:RIT1
Variant:p.A77S
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RIT1

NM_006912.6:p.A77S

Associated Papers

Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state.

Rominger MC et al.

Cell Reports, 2025

41004338 (PubMed )
Supplement: NIHMS2120069-supplement-2.xlsx › A_-_AACR_GENIE_v17

Genetic diseases underlying a spectrum of fetal effusions.

Gulrajani NB et al.

American Journal of Obstetrics and Gynecology, 2025

Advancing Non-Invasive Prenatal Screening: A Targeted 1069-Gene Panel for Comprehensive Detection of Monogenic Disorders and Copy Number Variations.

Sirica R et al.

Genes, 2025

Oncogenic RIT1 mutations confer ferroptosis vulnerability in lung adenocarcinoma.

Ma R et al.

Biology Direct, 2025

Correction to: Oncogenic RIT1 mutations in lung adenocarcinoma.

Berger AH et al.

Oncogene, 2022

Are transient protein-protein interactions more dispensable?

Ghadie MA et al.

Plos Computational Biology, 2022

35404956 (PubMed )
Supplement: pcbi.1010013.s002.xlsx › _B__Y2H-SI_disMut_edgotypes

Genomic Landscape of RTK/RAS Pathway and Tumor Immune Infiltration as Prognostic Indicator of Lung Adenocarcinoma.

Yin XQ et al.

Frontiers in Oncology, 2022

35936718 (PubMed )
Supplement: Table_4.xlsx › MAF_infomation

Mutation Edgotype Drives Fitness Effect in Human.

Ghadie M et al.

Frontiers in Bioinformatics, 2021

36303776 (PubMed )
Supplement: Table2.XLSX › _B__Y2H-SI_pathMt_edgotype

RIT1 controls actin dynamics via complex formation with RAC1/CDC42 and PAK1.

Meyer Zum Büschenfelde U et al.

Plos Genetics, 2018

Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1).

Fang Z et al.

The Journal of Biological Chemistry, 2016

Two cases of RIT1 associated Noonan syndrome: Further delineation of the clinical phenotype and review of the literature.

Milosavljević D et al.

American Journal of Medical Genetics. Part A, 2016

Spectrum of mutations and genotype-phenotype analysis in Noonan syndrome patients with RIT1 mutations.

Yaoita M et al.

Human Genetics, 2016

Oncogenic RIT1 mutations in lung adenocarcinoma.

Berger AH et al.

Oncogene, 2014

Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations.

Kiel C et al.

Molecular Systems Biology, 2014

24803665 (PubMed )
Supplement: MSB-10-5-727-s13.xls › energies
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."