Associated Papers
R-loop processing via REXO4-RNaseH1-mediated endo- and exo-cleavage coupling mode prevents genome instability and antitumor immunity.
Yang H et al.
Science Advances, 2026
A role for human senataxin in contending with pausing and backtracking during transcript elongation.
Han Z et al.
Molecular Cell, 2025
Autocrine interferon poisoning mediates ADAR1-dependent synthetic lethality in BRCA1/2-mutant cancers.
Chabanon RM et al.
Nature Communications, 2025
DNMT1 is required for efficient DSB repair and maintenance of replication fork stability, and its loss reverses resistance to PARP inhibitors in cancer cells.
Wu W et al.
Oncogene, 2025
NAT10 and N4-acetylcytidine restrain R-loop levels and related inflammatory responses.
Debnath TK et al.
Science Advances, 2025
YTHDC1 cooperates with the THO complex to prevent RNA-damage-induced DNA breaks.
Tsao N et al.
Molecular Cell, 2025
p53 activates circASCC3 to repress R-loops and enhance resistance to chemotherapy.
Cao M et al.
Proceedings of the National Academy of Sciences of the United States of America, 2025
p53-mediated regulation of LINE1 retrotransposon-derived R-loops.
Paul P et al.
The Journal of Biological Chemistry, 2025
The human HELQ helicase and XRN2 exoribonuclease cooperate in R-loop resolution.
Pan JM et al.
Open Biology, 2025
A novel DNA repair protein, N-Myc downstream regulated gene 1 (NDRG1), links stromal tumour microenvironment to chemoresistance.
Kozlova N et al.
Biorxiv : the Preprint Server for Biology, 2025
KLF5 loss sensitizes cells to ATR inhibition and is synthetic lethal with ARID1A deficiency.
Awwad SW et al.
Nature Communications, 2025
A mutant ASXL1-BAP1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia.
Dong Z et al.
Proceedings of the National Academy of Sciences of the United States of America, 2025
A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia.
Dong Z et al.
Biorxiv : the Preprint Server for Biology, 2025
Tetrameric INTS6-SOSS1 complex facilitates DNA:RNA hybrid autoregulation at double-strand breaks.
Long Q et al.
Nucleic Acids Research, 2024
The RNA-binding protein PCBP1 modulates transcription by recruiting the G-quadruplex-specific helicase DHX9.
Karam JAQ et al.
The Journal of Biological Chemistry, 2024
NAT10 resolves harmful nucleolar R-loops depending on its helicase domain and acetylation of DDX21.
Su K et al.
Cell Communication and Signaling : Ccs, 2024
Senataxin RNA/DNA helicase promotes replication restart at co-transcriptional R-loops to prevent MUS81-dependent fork degradation.
Rao S et al.
Nucleic Acids Research, 2024
PCAF promotes R-loop resolution via histone acetylation.
Lee SY et al.
Nucleic Acids Research, 2024
Senataxin deficiency disrupts proteostasis through nucleolar ncRNA-driven protein aggregation.
Wen X et al.
The Journal of Cell Biology, 2024
Impaired binding affinity of YTHDC1 with METTL3/METTL14 results in R-loop accumulation in myelodysplastic neoplasms with DDX41 mutation.
Hwang WC et al.
Leukemia, 2024
Nucleolar detention of NONO shields DNA double-strand breaks from aberrant transcripts.
Trifault B et al.
Nucleic Acids Research, 2024
Transcription-replication conflicts underlie sensitivity to PARP inhibitors.
Petropoulos M et al.
Nature, 2024
RTF2 controls replication repriming and ribonucleotide excision at the replisome.
Conti BA et al.
Nature Communications, 2024
RNA helicase DDX3 regulates RAD51 localization and DNA damage repair in Ewing sarcoma.
Randolph ME et al.
Iscience, 2024
R-Loop Accumulation in Spliceosome Mutant Leukemias Confers Sensitivity to PARP1 Inhibition by Triggering Transcription-Replication Conflicts.
Liu ZS et al.
Cancer Research, 2024
MutSβ-MutLβ-FANCJ axis mediates the restart of DNA replication after fork stalling at cotranscriptional G4/R-loops.
Isik E et al.
Science Advances, 2024
Structures, functions and adaptations of the human LINE-1 ORF2 protein.
Baldwin ET et al.
Nature, 2024
The phosphorylated trimeric SOSS1 complex and RNA polymerase II trigger liquid-liquid phase separation at double-strand breaks.
Long Q et al.
Cell Reports, 2023
RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells.
Krishnan R et al.
Nucleic Acids Research, 2023
Promoter R-Loops Recruit U2AF1 to Modulate Its Phase Separation and RNA Splicing.
He X et al.
Journal of the American Chemical Society, 2023
RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma.
Randolph ME et al.
Biorxiv : the Preprint Server for Biology, 2023
Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers.
Patel PS et al.
Nucleic Acids Research, 2023
Homology directed telomere clustering, ultrabright telomere formation and nuclear envelope rupture in cells lacking TRF2B and RAP1.
Rai R et al.
Nature Communications, 2023
Excessive reactive oxygen species induce transcription-dependent replication stress.
Andrs M et al.
Nature Communications, 2023
HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression.
Refaat AM et al.
Cell Reports, 2023
RTF2 controls replication repriming and ribonucleotide excision at the replisome.
Conti BA et al.
Biorxiv : the Preprint Server for Biology, 2023
The BRCA1 BRCT promotes antisense RNA production and double-stranded RNA formation to suppress ribosomal R-loops.
Chang CW et al.
Proceedings of the National Academy of Sciences of the United States of America, 2022
DDX17 helicase promotes resolution of R-loop-mediated transcription-replication conflicts in human cells.
Boleslavska B et al.
Nucleic Acids Research, 2022
DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells.
Shinriki S et al.
Leukemia, 2022
Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells.
Groelly FJ et al.
Molecular Cell, 2022
FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation.
Yang H et al.
Proceedings of the National Academy of Sciences of the United States of America, 2022
Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors.
Lappin KM et al.
Cancer Research, 2022
TET deficiency perturbs mature B cell homeostasis and promotes oncogenesis associated with accumulation of G-quadruplex and R-loop structures.
Shukla V et al.
Nature Immunology, 2022