Varaico: Literature-Extracted Genetic Variants

Gene:RNASEH1
Variant:p.D145N
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RNASEH1

NM_002936.6:p.D145N

Associated Papers

Crosstalk between chromatin state and ATM signalling in DNA damage-induced transcription stress.

Salas-Armenteros I et al.

The Embo Journal, 2025

R-loop landscapes in the developing human brain are linked to neural differentiation and cell-type specific transcription.

LaMarca EA et al.

Biorxiv : the Preprint Server for Biology, 2023

MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage.

Kalev P et al.

Cancer Cell, 2021

TDP-43 dysfunction results in R-loop accumulation and DNA replication defects.

Wood M et al.

Journal of Cell Science, 2020

Human ribonuclease H1 resolves R-loops and thereby enables progression of the DNA replication fork.

Parajuli S et al.

The Journal of Biological Chemistry, 2017

A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability.

Tan SLW et al.

Cell, 2017

The core spliceosome as target and effector of non-canonical ATM signalling.

Tresini M et al.

Nature, 2015

Investigating the structure of human RNase H1 by site-directed mutagenesis.

Wu H et al.

The Journal of Biological Chemistry, 2001

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."