Varaico: Literature-Extracted Genetic Variants

Gene:RNF168
Variant:p.A450G
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RNF168

NM_152617.4:p.A450G

Associated Papers

USP14 regulates DNA damage repair by targeting RNF168-dependent ubiquitination.

Sharma A et al.

Autophagy, 2018

Retroviral insertional mutagenesis implicates E3 ubiquitin ligase RNF168 in the control of cell proliferation and survival.

Kizilors A et al.

Bioscience Reports, 2017

RNF111-dependent neddylation activates DNA damage-induced ubiquitination.

Ma T et al.

Molecular Cell, 2013

A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure.

Luijsterburg MS et al.

The Embo Journal, 2012

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.

Stewart GS et al.

Cell, 2009

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.

Doil C et al.

Cell, 2009

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."