Associated Papers
RNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair.
Katsuki Y et al.
Cell Reports, 2021
RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors.
Patel PS et al.
The Journal of Clinical Investigation, 2021
RNF168-Mediated Ubiquitin Signaling Inhibits the Viability of BRCA1-Null Cancers.
Krais JJ et al.
Cancer Research, 2020
Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress.
Chroma K et al.
Oncogene, 2017
Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage.
Thorslund T et al.
Nature, 2015
The histone demethylase LSD1/KDM1A promotes the DNA damage response.
Mosammaparast N et al.
The Journal of Cell Biology, 2013
24217620 (PubMed )
Supplement: supp_jcb.201302092_JCB_201302092_sm.pdf
A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure.
Luijsterburg MS et al.
The Embo Journal, 2012
Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks.
Poulsen M et al.
The Journal of Cell Biology, 2012
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.
Doil C et al.
Cell, 2009
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