Associated Papers
Identification of a disease-associated germline mutation (A64T) of the ring finger protein 186 gene (RNF186) in Korean patients with ulcerative colitis.
Park SH et al.
Genes & Diseases, 2025
RNF186 gene variant and zonulin levels in inflammatory bowel disease: A pilot study.
Güneri EÖ et al.
Arab Journal of Gastroenterology : the Official Publication of the Pan-arab Association of Gastroenterology, 2025
RNF186/EPHB2 Axis Is Essential in Regulating TNF Signaling for Colorectal Tumorigenesis in Colorectal Epithelial Cells.
Zhang H et al.
Journal of Immunology (baltimore, Md. : 1950), 2022
An explainable model of host genetic interactions linked to COVID-19 severity.
Onoja A et al.
Communications Biology, 2022
Molecular networks of hepatoblastoma predisposition and oncogenesis in Beckwith-Wiedemann syndrome.
Sobel Naveh NS et al.
Hepatology Communications, 2022
Functional screen of inflammatory bowel disease genes reveals key epithelial functions.
Ntunzwenimana JC et al.
Genome Medicine, 2021
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Zhang H et al.
Autophagy, 2021
Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response.
Ranjan K et al.
The Journal of Clinical Investigation, 2021
The E3 ubiquitin ligase RNF186 and RNF186 risk variants regulate innate receptor-induced outcomes.
Ranjan K et al.
Proceedings of the National Academy of Sciences of the United States of America, 2021
The Roles of Post-Translational Modifications on mTOR Signaling.
Yin S et al.
International Journal of Molecular Sciences, 2021
Pathway paradigms revealed from the genetics of inflammatory bowel disease.
Graham DB et al.
Nature, 2020
Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186.
Fujimoto K et al.
Mucosal Immunology, 2017
The genetic background of inflammatory bowel disease: from correlation to causality.
Uniken Venema WT et al.
The Journal of Pathology, 2017
Genetic Complexity of Crohn's Disease in Two Large Ashkenazi Jewish Families.
Levine AP et al.
Gastroenterology, 2016
A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.
Rivas MA et al.
Nature Communications, 2016
Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis.
Beaudoin M et al.
Plos Genetics, 2013