Associated Papers
M1-linked ubiquitination by LUBAC regulates AMPK signalling and the response to energetic stress.
Elbæk CR et al.
Cell Death and Differentiation, 2026
Spatiotemporal Regulation of STING Activity by Linear Ubiquitination Governs Antiviral Immunity.
Zhang Y et al.
Advanced Science (weinheim, Baden-wurttemberg, Germany), 2025
Linear ubiquitination of p31comet by HOIP couples cytokine response with mitotic regulation.
Gao Y et al.
Cell & Bioscience, 2025
Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis.
Fu Y et al.
Nature Communications, 2024
Linear ubiquitination induces NEMO phase separation to activate NF-κB signaling.
Goel S et al.
Life Science Alliance, 2023
HOIP modulates the stability of GPx4 by linear ubiquitination.
Dong K et al.
Proceedings of the National Academy of Sciences of the United States of America, 2022
LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole.
Shen XL et al.
The Journal of Cell Biology, 2022
LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13.
Chu Y et al.
Autophagy, 2021
Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP.
Johansson H et al.
Journal of the American Chemical Society, 2019
Linear ubiquitination of cFLIP induced by LUBAC contributes to TNFα-induced apoptosis.
Tang Y et al.
The Journal of Biological Chemistry, 2018
TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation.
Lafont E et al.
Nature Cell Biology, 2018
The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death.
Lafont E et al.
The Embo Journal, 2017
Molecular Determinants of Scaffold-induced Linear Ubiquitinylation of B Cell Lymphoma/Leukemia 10 (Bcl10) during T Cell Receptor and Oncogenic Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling.
Yang YK et al.
The Journal of Biological Chemistry, 2016
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
Kupka S et al.
Cell Reports, 2016
Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation.
Pao KC et al.
Nature Chemical Biology, 2016
Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation.
Bowman J et al.
Mbio, 2015
UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases.
Lewis MJ et al.
American Journal of Human Genetics, 2015
TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.
Rickard JA et al.
Elife, 2014
HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death.
Peltzer N et al.
Cell Reports, 2014
The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension.
Smit JJ et al.
The Embo Journal, 2012
LUBAC synthesizes linear ubiquitin chains via a thioester intermediate.
Stieglitz B et al.
Embo Reports, 2012