Associated Papers
MLH1 Lynch Syndrome Colorectal Cancers Are Driven by Heterogeneous Wnt Pathway Gene Mutations.
Hokkanen KE et al.
Gastroenterology, 2026
Diagnostic Challenges and Clinical Implications of Microsatellite Instability/Mismatch Repair Deficiency in Solid Tumors.
Kwak Y et al.
Cancer Research and Treatment, 2026
Molecular analysis of the evolutionary history of endometrial and ovarian carcinoma in Lynch syndrome.
Kauppinen AK et al.
International Journal of Cancer, 2025
Immunohistochemical "null" pattern of all four mismatch repair proteins in Lynch syndrome-associated small bowel adenocarcinoma: a case report and comprehensive genomic profiling.
Kageyama S et al.
Virchows Archiv : an International Journal of Pathology, 2025
A neomorphic protein interface catalyzes covalent inhibition of RASG12D aspartic acid in tumors.
Weller C et al.
Science (new York, N.y.), 2025
Generative prediction of causal gene sets responsible for complex traits.
Kuznets-Speck B et al.
Proceedings of the National Academy of Sciences of the United States of America, 2025
Lack of dominant-negative activity for tumor-related ZNRF3 missense mutations at endogenous levels.
Li S et al.
Oncogene, 2025
Microsatellite-high intrahepatic cholangiocarcinoma with favorable treatment outcome using pembrolizumab.
Horiguchi S et al.
Clinical Journal of Gastroenterology, 2025
Comprehensive genomic dependency landscape of a human colon cancer organoid.
Khalili S et al.
Communications Biology, 2025
Clinical Validation of Local Versus Commercial Genomic Testing in Cancer: A Comparison of Tissue and Plasma Concordance.
Faulkner LG et al.
Cancer Investigation, 2025
RNA hybrid-capture next-generation sequencing has high sensitivity in identifying known and less characterized oncogenic and likely oncogenic NTRK fusions in a real-world standard-of-care setting.
Wallen ZD et al.
Frontiers in Genetics, 2025
Decoding the molecular landscape: HER2 and PD-L1 in advanced gastric cancer.
Yao J et al.
Frontiers in Immunology, 2025
Define a good prognosis of RNF43 codon 659-mutated and concomitant genomic signatures in CRC: an analysis of the cBioPortal database.
Wang F et al.
Frontiers in Oncology, 2025
Single-Hit and Multi-hit PIK3CA Short Variant Genomic Alterations in Clinically Advanced Prostate Cancer: A Genomic Landscape Study.
Basin MF et al.
Targeted Oncology, 2024
RNF43 and ZNRF3: Versatile regulators at the membrane and their role in cancer.
Li S et al.
Biochimica Et Biophysica Acta. Reviews on Cancer, 2024
Large-scale analysis of whole genome sequencing data from formalin-fixed paraffin-embedded cancer specimens demonstrates preservation of clinical utility.
Basyuni S et al.
Nature Communications, 2024
RNF43 in cancer: Molecular understanding and clinical significance in immunotherapy.
Huo X et al.
The Journal of Gene Medicine, 2024
New Target(s) for RNF43 Regulation: Implications for Therapeutic Strategies.
Nag JK et al.
International Journal of Molecular Sciences, 2024
Molecular profiling of pediatric and young adult colorectal cancer reveals a distinct genomic landscapes and potential therapeutic avenues.
Busico A et al.
Scientific Reports, 2024
Integrative Molecular Analyses of the MD Anderson Prostate Cancer Patient-derived Xenograft (MDA PCa PDX) Series.
Anselmino N et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2024
New insights in ubiquitin-dependent Wnt receptor regulation in tumorigenesis.
Tsukiyama T
In Vitro Cellular & Developmental Biology. Animal, 2024
Genomic profiling and clinical utility of circulating tumor DNA in metastatic prostate cancer: SCRUM-Japan MONSTAR SCREEN project.
Shiota M et al.
Bjc Reports, 2024
Mucin phenotype and genetic alterations in non-V600E BRAF-mutated colorectal cancer.
Ozeki H et al.
Human Pathology, 2024
Clinical and molecular characteristics of RNF43 mutations as promising prognostic biomarkers in colorectal cancer.
Huang ZY et al.
Therapeutic Advances in Medical Oncology, 2024
Novel insights into tumorigenesis revealed by molecular analysis of Lynch syndrome cases with multiple colorectal tumors.
Olkinuora A et al.
Frontiers in Oncology, 2024
Genomic profiling of ovarian clear cell carcinoma in Chinese patients reveals potential prognostic biomarkers for survival.
Ye S et al.
Annals of Medicine, 2023
Subclonal accumulation of immune escape mechanisms in microsatellite instability-high colorectal cancers.
Kobayashi Y et al.
British Journal of Cancer, 2023
Concordance between cancer gene alterations in tumor and circulating tumor DNA correlates with poor survival in a real-world precision-medicine population.
Rosenberg S et al.
Molecular Oncology, 2023
Parathyroid carcinoma: molecular therapeutic targets.
Marini F et al.
Endocrine, 2023
Molecular profiling of colorectal cancer in a genetically admixed Hispanic population.
Montes-Rodríguez IM et al.
Cancer Medicine, 2023
Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens.
Ishino T et al.
British Journal of Cancer, 2023
The Role of WNT Pathway Mutations in Cancer Development and an Overview of Therapeutic Options.
Groenewald W et al.
Cells, 2023
The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations.
Villani A et al.
Nature Cancer, 2023
Case report: Complete and durable response to larotrectinib (TRK inhibitor) in an infant diagnosed with angiosarcoma harbouring a KHDRBS1-NTRK3 fusion gene.
Cervi C et al.
Frontiers in Oncology, 2023
Development and validation of a mutation-based model to predict immunotherapeutic efficacy in NSCLC.
He P et al.
Frontiers in Oncology, 2023
RNF43 mutation as a predictor of immunotherapeutic efficacy in colorectal cancer.
Huang K et al.
American Journal of Cancer Research, 2023
A Comprehensive Biomarker Analysis of Microsatellite Unstable/Mismatch Repair Deficient Colorectal Cancer Cohort Treated with Immunotherapy.
Élez E et al.
International Journal of Molecular Sciences, 2022
RNF43 mutations predict response to anti-BRAF/EGFR combinatory therapies in BRAFV600E metastatic colorectal cancer.
Elez E et al.
Nature Medicine, 2022
An expression-based variant impact phenotyping protocol to predict the impact of gene variants in cell lines.
Thornton AM et al.
Star Protocols, 2022
A Case Report of Immunotherapy-Resistant MSI-H Gastric Cancer with Significant Intrapatient Tumoral Heterogeneity Characterized by Histologic Dedifferentiation.
Kethireddy N et al.
Journal of Clinical Medicine, 2022
RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.
Fang L et al.
Nature Communications, 2022