Associated Papers
Lack of dominant-negative activity for tumor-related ZNRF3 missense mutations at endogenous levels.
Li S et al.
Oncogene, 2025
New Target(s) for RNF43 Regulation: Implications for Therapeutic Strategies.
Nag JK et al.
International Journal of Molecular Sciences, 2024
New insights in ubiquitin-dependent Wnt receptor regulation in tumorigenesis.
Tsukiyama T
In Vitro Cellular & Developmental Biology. Animal, 2024
Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens.
Ishino T et al.
British Journal of Cancer, 2023
RNF43 mutations predict response to anti-BRAF/EGFR combinatory therapies in BRAFV600E metastatic colorectal cancer.
Elez E et al.
Nature Medicine, 2022
The Functional Landscape of Patient-Derived RNF43 Mutations Predicts Sensitivity to Wnt Inhibition.
Yu J et al.
Cancer Research, 2020
A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis.
Tsukiyama T et al.
Nature Communications, 2020
RNF43 truncations trap CK1 to drive niche-independent self-renewal in cancer.
Spit M et al.
The Embo Journal, 2020
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