Associated Papers
The Cullin3-Ring E3 ubiquitin ligase complex and USP14 regulate spastin-mediated microtubule severing and promotion of neurite outgrowth.
Cai Z et al.
Neural Regeneration Research, 2026
SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation.
Li W et al.
The Embo Journal, 2025
Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase.
Carrillo Roas S et al.
Molecular Cell, 2025
E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9A.
Hao X et al.
The Embo Journal, 2025
Sugar-mediated non-canonical ubiquitination impairs Nrf1/NFE2L1 activation.
Yoshida Y et al.
Molecular Cell, 2024
K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.
Waltho A et al.
Life Science Alliance, 2024
The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs.
Yang S et al.
Molecular Cell, 2024
Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5.
Hehl LA et al.
Nature Chemical Biology, 2024
PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly.
Chou MC et al.
Molecular Cell, 2023
The E3 ubiquitin ligase CHIP drives monoubiquitylation-mediated nuclear import of the tumor suppressor PTEN.
Chakraborty S et al.
Journal of Cell Science, 2023
Hyperubiquitylation of DNA helicase RECQL4 by E3 ligase MITOL prevents mitochondrial entry and potentiates mitophagy.
Hussain M et al.
The Journal of Biological Chemistry, 2023
Orphan quality control shapes network dynamics and gene expression.
Mark KG et al.
Cell, 2023
RUNX3 inactivates oncogenic MYC through disruption of MYC/MAX complex and subsequent recruitment of GSK3β-FBXW7 cascade.
Oei V et al.
Communications Biology, 2023
Lipid kinase PIP5Kα contributes to Hippo pathway activation via interaction with Merlin and by mediating plasma membrane targeting of LATS1.
Le TPH et al.
Cell Communication and Signaling : Ccs, 2023
Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin.
Wydorski PM et al.
Biorxiv : the Preprint Server for Biology, 2023
CDK1-cyclin-B1-induced kindlin degradation drives focal adhesion disassembly at mitotic entry.
Chen NP et al.
Nature Cell Biology, 2022
SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones.
Nakagawa T et al.
Cell Reports, 2022
K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy.
Wang YT et al.
Cell Reports, 2022
Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase.
Ji Z et al.
Molecular Cell, 2022
PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis.
Linares JF et al.
Molecular Cell, 2021
Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination.
Zhang L et al.
Cell Reports, 2021
Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2.
Abdul Rehman SA et al.
Molecular Cell, 2021
A20 Inhibits LPS-Induced Inflammation by Regulating TRAF6 Polyubiquitination in Rainbow Trout.
Jang JH et al.
International Journal of Molecular Sciences, 2021
TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity.
Fan W et al.
Cell, 2021
NSMF promotes the replication stress-induced DNA damage response for genome maintenance.
Ju MK et al.
Nucleic Acids Research, 2021
The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63-branched ubiquitin chains.
Pluska L et al.
The Embo Journal, 2021
MITOL-dependent ubiquitylation negatively regulates the entry of PolγA into mitochondria.
Hussain M et al.
Plos Biology, 2021
The ubiquitin ligase RFWD3 is required for translesion DNA synthesis.
Gallina I et al.
Molecular Cell, 2021
Hepatitis B Core Protein Is Post-Translationally Modified through K29-Linked Ubiquitination.
Langerová H et al.
Cells, 2020
Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair.
Nakazawa Y et al.
Cell, 2020
Stepwise multipolyubiquitination of p53 by the E6AP-E6 ubiquitin ligase complex.
Masuda Y et al.
The Journal of Biological Chemistry, 2019
BLM Potentiates c-Jun Degradation and Alters Its Function as an Oncogenic Transcription Factor.
Priyadarshini R et al.
Cell Reports, 2018
Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.
Yau RG et al.
Cell, 2017
Grb2-Mediated Recruitment of USP9X to LAT Enhances Themis Stability following Thymic Selection.
Garreau A et al.
Journal of Immunology (baltimore, Md. : 1950), 2017
Structural and Functional Investigations of the N-Terminal Ubiquitin Binding Region of Usp25.
Yang Y et al.
Biophysical Journal, 2017
TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A Expression.
Wang X et al.
The Journal of Biological Chemistry, 2015
The N-terminal ubiquitin-binding region of ubiquitin-specific protease 28 modulates its deubiquitination function: NMR structural and mechanistic insights.
Wen Y et al.
The Biochemical Journal, 2015
Differential ubiquitin binding by the acidic loops of Ube2g1 and Ube2r1 enzymes distinguishes their Lys-48-ubiquitylation activities.
Choi YS et al.
The Journal of Biological Chemistry, 2015
Systematic exploration of ubiquitin sequence, E1 activation efficiency, and experimental fitness in yeast.
Roscoe BP et al.
Journal of Molecular Biology, 2014
Binding of HIV-1 Vpr protein to the human homolog of the yeast DNA repair protein RAD23 (hHR23A) requires its xeroderma pigmentosum complementation group C binding (XPCB) domain as well as the ubiquitin-associated 2 (UBA2) domain.
Jung J et al.
The Journal of Biological Chemistry, 2014
TRIM68 negatively regulates IFN-β production by degrading TRK fused gene, a novel driver of IFN-β downstream of anti-viral detection systems.
Wynne C et al.
Plos One, 2014
Assembly, analysis and architecture of atypical ubiquitin chains.
Hospenthal MK et al.
Nature Structural & Molecular Biology, 2013
Importance of the N-terminal domain of the Qb-SNARE Vti1p for different membrane transport steps in the yeast endosomal system.
Gossing M et al.
Plos One, 2013
Structure of the HECT C-lobe of the UBR5 E3 ubiquitin ligase.
Matta-Camacho E et al.
Acta Crystallographica. Section F, Structural Biology and Crystallization Communications, 2012
Degradation of p21Cip1 through anaphase-promoting complex/cyclosome and its activator Cdc20 (APC/CCdc20) ubiquitin ligase complex-mediated ubiquitylation is inhibited by cyclin-dependent kinase 2 in cardiomyocytes.
Yamada K et al.
The Journal of Biological Chemistry, 2011
Niclosamide prevents the formation of large ubiquitin-containing aggregates caused by proteasome inhibition.
Gies E et al.
Plos One, 2010
Effect of the overexpression of mutant ubiquitin (K48R) on the cellular response induced by 4-hydroxy-2,3-trans-nonenal, an end-product of lipid peroxidation.
Hyun DH
Neuroscience Letters, 2010
Atypical binding of the Swa2p UBA domain to ubiquitin.
Matta-Camacho E et al.
Journal of Molecular Biology, 2009