Associated Papers
The Cullin3-Ring E3 ubiquitin ligase complex and USP14 regulate spastin-mediated microtubule severing and promotion of neurite outgrowth.
Cai Z et al.
Neural Regeneration Research, 2026
E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9A.
Hao X et al.
The Embo Journal, 2025
Linkage-specific ubiquitin binding interfaces modulate the activity of the chlamydial deubiquitinase Cdu1 towards poly-ubiquitin substrates.
Schlötzer J et al.
Plos Pathogens, 2024
Sugar-mediated non-canonical ubiquitination impairs Nrf1/NFE2L1 activation.
Yoshida Y et al.
Molecular Cell, 2024
K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.
Waltho A et al.
Life Science Alliance, 2024
Hyperubiquitylation of DNA helicase RECQL4 by E3 ligase MITOL prevents mitochondrial entry and potentiates mitophagy.
Hussain M et al.
The Journal of Biological Chemistry, 2023
Orphan quality control shapes network dynamics and gene expression.
Mark KG et al.
Cell, 2023
E2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation.
Ravichandran KE et al.
The Embo Journal, 2022
Redox-sensitive E2 Rad6 controls cellular response to oxidative stress via K63-linked ubiquitination of ribosomes.
Simões V et al.
Cell Reports, 2022
SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones.
Nakagawa T et al.
Cell Reports, 2022
K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy.
Wang YT et al.
Cell Reports, 2022
PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis.
Linares JF et al.
Molecular Cell, 2021
Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination.
Zhang L et al.
Cell Reports, 2021
A20 Inhibits LPS-Induced Inflammation by Regulating TRAF6 Polyubiquitination in Rainbow Trout.
Jang JH et al.
International Journal of Molecular Sciences, 2021
NSMF promotes the replication stress-induced DNA damage response for genome maintenance.
Ju MK et al.
Nucleic Acids Research, 2021
MITOL-dependent ubiquitylation negatively regulates the entry of PolγA into mitochondria.
Hussain M et al.
Plos Biology, 2021
The ubiquitin ligase RFWD3 is required for translesion DNA synthesis.
Gallina I et al.
Molecular Cell, 2021
Structural basis for the multi-activity factor Rad5 in replication stress tolerance.
Shen M et al.
Nature Communications, 2021
Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair.
Nakazawa Y et al.
Cell, 2020
STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection.
Wang W et al.
Plos Pathogens, 2020
Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.
Rabl J et al.
Molecular Cell, 2019
BLM Potentiates c-Jun Degradation and Alters Its Function as an Oncogenic Transcription Factor.
Priyadarshini R et al.
Cell Reports, 2018
Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.
Yau RG et al.
Cell, 2017
TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A Expression.
Wang X et al.
The Journal of Biological Chemistry, 2015
RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks.
Elia AE et al.
Molecular Cell, 2015
TRIM68 negatively regulates IFN-β production by degrading TRK fused gene, a novel driver of IFN-β downstream of anti-viral detection systems.
Wynne C et al.
Plos One, 2014
Lys63-linked polyubiquitination of BRAF at lysine 578 is required for BRAF-mediated signaling.
An L et al.
Scientific Reports, 2013
Niclosamide prevents the formation of large ubiquitin-containing aggregates caused by proteasome inhibition.
Gies E et al.
Plos One, 2010
Disease-associated mutant ubiquitin causes proteasomal impairment and enhances the toxicity of protein aggregates.
Tank EM et al.
Plos Genetics, 2009
The ubiquitin-proteasome system in spongiform degenerative disorders.
Whatley BR et al.
Biochimica Et Biophysica Acta, 2008
Formation of lysine 63-linked poly-ubiquitin chains protects human lung cells against benzo[a]pyrene-diol-epoxide-induced mutagenicity.
Langie SA et al.
Dna Repair, 2007
Sensitivity of mammalian cells expressing mutant ubiquitin to protein-damaging agents.
Tsirigotis M et al.
The Journal of Biological Chemistry, 2001
Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain.
Spence J et al.
Cell, 2000