Associated Papers
Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex.
Lupton CJ et al.
Cell, 2026
Global conformation of the Rag GTPase heterodimer governs eukaryotic amino acid sensing.
Doxsey DD et al.
Proceedings of the National Academy of Sciences of the United States of America, 2025
TFEB drives mTORC1 hyperactivation and kidney disease in Tuberous Sclerosis Complex.
Alesi N et al.
Nature Communications, 2024
Structure of the Schizosaccharomyces pombe Gtr-Lam complex reveals evolutionary divergence of mTORC1-dependent amino acid sensing.
Tettoni SD et al.
Structure (london, England : 1993), 2023
GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion-positive rhabdomyosarcoma.
Morales J et al.
Jci Insight, 2022
Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation.
Chen X et al.
Nature Communications, 2022
A New Crosslinking Assay to Study Guanine Nucleotide Binding in the Gtr Heterodimer of S. cerevisiae.
Doxsey DD et al.
Small Gtpases, 2022
Purification and biochemical characterization of the Rag GTPase heterodimer.
Doxsey DD et al.
Methods in Enzymology, 2022
The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction.
Yang S et al.
Developmental Cell, 2020
A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome.
Napolitano G et al.
Nature, 2020
Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex.
Shen K et al.
Cell, 2019
Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Anandapadamanaban M et al.
Science (new York, N.y.), 2019
Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.
Shen K et al.
Nature, 2018
Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1.
Zhang T et al.
Nature Communications, 2017
Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.
Shen K et al.
Molecular Cell, 2017
Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.
de Araujo MEG et al.
Science (new York, N.y.), 2017
Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane.
Mu Z et al.
Cell Discovery, 2017
Amino acid-dependent NPRL2 interaction with Raptor determines mTOR Complex 1 activation.
Kwak SS et al.
Cellular Signalling, 2016
The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation.
Deng L et al.
Molecular Cell, 2015
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
Rebsamen M et al.
Nature, 2015
The amino acid transporter SLC38A9 regulates MTORC1 and autophagy.
Jin M et al.
Autophagy, 2015
Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging.
Oshiro N et al.
The Journal of Biological Chemistry, 2014
The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.
Tsun ZY et al.
Molecular Cell, 2013