Associated Papers
VWCE modulates amino acid-dependent mTOR signaling and coordinates with KICSTOR to recruit GATOR1 to the lysosomes.
Zhao T et al.
Nature Communications, 2023
KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity.
Yan G et al.
Autophagy, 2022
Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3.
Villegas F et al.
Cell Stem Cell, 2019
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.
Wolfson RL et al.
Nature, 2017
Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1.
Schweitzer LD et al.
Cell Reports, 2015
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
Wang S et al.
Science (new York, N.y.), 2015
The amino acid transporter SLC38A9 regulates MTORC1 and autophagy.
Jin M et al.
Autophagy, 2015
The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.
Tsun ZY et al.
Molecular Cell, 2013
A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
Bar-Peled L et al.
Science (new York, N.y.), 2013
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.
Bar-Peled L et al.
Cell, 2012
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