Associated Papers
Identification of genetic subtypes in follicular lymphoma.
Shelton V et al.
Blood Cancer Journal, 2024
Ragopathies and the rising influence of RagGTPases on human diseases.
Sambri I et al.
Nature Communications, 2024
RRAGD-Associated Autosomal Dominant Kidney Hypomagnesemia with Cardiomyopathy: A Review on the Clinical Manifestations and Therapeutic Options.
Trepiccione F et al.
Kidney & Blood Pressure Research, 2024
Raptor mediates the selective inhibitory effect of cardamonin on RRAGC-mutant B cell lymphoma.
Liu Y et al.
Bmc Complementary Medicine and Therapies, 2023
De novo missense variants in RRAGC lead to a fatal mTORopathy of early childhood.
Reijnders MRF et al.
Genetics in Medicine : Official Journal of the American College of Medical Genetics, 2023
A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids.
Gollwitzer P et al.
Nature Cell Biology, 2022
Human B Lymphomas Reveal Their Secrets Through Genetic Mouse Models.
Mossadegh-Keller N et al.
Frontiers in Immunology, 2021
Amino Acid Sensing: Architecture of mTORC1 on the Lysosome Surface.
Peng W et al.
Current Biology : Cb, 2020
Structural basis for the docking of mTORC1 on the lysosomal surface.
Rogala KB et al.
Science (new York, N.y.), 2019
Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Anandapadamanaban M et al.
Science (new York, N.y.), 2019
Oncogenic Rag GTPase signaling enhances B cell activation and drives follicular lymphoma sensitive to pharmacological inhibition of mTOR.
Ortega-Molina A et al.
Nature Metabolism, 2019
A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold.
Lawrence RE et al.
Nature Cell Biology, 2018
Recurrent Mutations in the MTOR Regulator RRAGC in Follicular Lymphoma.
Ying ZX et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2016
Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.
Okosun J et al.
Nature Genetics, 2016