Associated Papers
The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance.
Xu Y et al.
Immunity, 2025
MORG1 limits mTORC1 signaling by inhibiting Rag GTPases.
Abudu YP et al.
Molecular Cell, 2024
O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine.
Kim K et al.
Nature Communications, 2022
Genomic Alterations in PIK3CA-Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors.
Cai Y et al.
Cancer Research, 2021
Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation.
Kim S et al.
Cell Reports, 2021
Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3.
Villegas F et al.
Cell Stem Cell, 2019
The TMEM127 human tumor suppressor is a component of the mTORC1 lysosomal nutrient-sensing complex.
Deng Y et al.
Human Molecular Genetics, 2018
Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction.
Kim JH et al.
Nature Communications, 2017
Multistep regulation of TFEB by MTORC1.
Vega-Rubin-de-Celis S et al.
Autophagy, 2017
Amino acid-dependent NPRL2 interaction with Raptor determines mTOR Complex 1 activation.
Kwak SS et al.
Cellular Signalling, 2016
Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases.
Petit CS et al.
The Journal of Cell Biology, 2013
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway.
Han JM et al.
Cell, 2012
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.
Settembre C et al.
The Embo Journal, 2012
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