Associated Papers
Ras-Related Mutants Identified in Young-Onset Colorectal Cancer Display Divergent Phenotypes and Retain Their Pro-Angiogenic Effects.
David APL et al.
Cells, 2026
RRAS and RRAS2 mutations are recurrent oncogenic drivers in lung cancer and are sensitive to the pan-RAS inhibitor RMC-6236.
Pfeil AJ et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2026
RRAS and RRAS2 mutations are recurrent oncogenic drivers in lung cancer and are sensitive to the pan-RAS inhibitor RMC-6236.
Pfeil AJ et al.
Biorxiv : the Preprint Server for Biology, 2025
Mosaic RASopathies: A review of disorders caused by somatic pathogenic variants in the genes of the RAS/MAPK pathway.
Carli D et al.
American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, 2022
Genomic landscape of patients with FLT3-mutated acute myeloid leukemia (AML) treated within the CALGB 10603/RATIFY trial.
Jahn N et al.
Leukemia, 2022
Genomic and Epigenomic Landscape of Juvenile Myelomonocytic Leukemia.
Fiñana C et al.
Cancers, 2022
The RASopathies: from pathogenetics to therapeutics.
Hebron KE et al.
Disease Models & Mechanisms, 2022
The RRAS2 pathogenic variant p.Q72L produces severe Noonan syndrome with hydrocephalus: A case report.
Weinstock NI et al.
American Journal of Medical Genetics. Part A, 2022
The acquisition of molecular drivers in pediatric therapy-related myeloid neoplasms.
Schwartz JR et al.
Nature Communications, 2021
Disease burden and conditioning regimens in ASCT1221, a randomized phase II trial in children with juvenile myelomonocytic leukemia: A Children's Oncology Group study.
Dvorak CC et al.
Pediatric Blood & Cancer, 2018
The genomic landscape of pediatric myelodysplastic syndromes.
Schwartz JR et al.
Nature Communications, 2017
An Oncogenic ALK Fusion and an RRAS Mutation in KRAS Mutation-Negative Pancreatic Ductal Adenocarcinoma.
Shimada Y et al.
The Oncologist, 2017
The genomic landscape of juvenile myelomonocytic leukemia.
Stieglitz E et al.
Nature Genetics, 2015
A short splicing isoform of afadin suppresses the cortical axon branching in a dominant-negative manner.
Umeda K et al.
Molecular Biology of the Cell, 2015
Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis.
Flex E et al.
Human Molecular Genetics, 2014
R-Ras controls axon branching through afadin in cortical neurons.
Iwasawa N et al.
Molecular Biology of the Cell, 2012
Semaphorin 4D/Plexin-B1 stimulates PTEN activity through R-Ras GTPase-activating protein activity, inducing growth cone collapse in hippocampal neurons.
Oinuma I et al.
The Journal of Biological Chemistry, 2010
Structure and function of the intracellular region of the plexin-b1 transmembrane receptor.
Tong Y et al.
The Journal of Biological Chemistry, 2009
The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function.
Oertli B et al.
Oncogene, 2000