Associated Papers
The small GTPase MRAS is a broken switch.
Bernal Astrain G et al.
Nature Communications, 2025
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy.
Holderfield M et al.
Nature, 2024
The leucine-rich region of Flightless I interacts with R-ras to regulate cell extension formation.
Arora PD et al.
Molecular Biology of the Cell, 2018
ERK1/2-induced phosphorylation of R-Ras GTPases stimulates their oncogenic potential.
Frémin C et al.
Oncogene, 2016
RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes.
Wurtzel JG et al.
Biochemical and Biophysical Research Communications, 2015
OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity.
Weber-Boyvat M et al.
Experimental Cell Research, 2015
The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling.
Sandri C et al.
Cell Research, 2012
R-Ras regulates migration through an interaction with filamin A in melanoma cells.
Gawecka JE et al.
Plos One, 2010
Oncogenic mutations regulate tumor microenvironment through induction of growth factors and angiogenic mediators.
Wang SE et al.
Oncogene, 2010
Palmitoylation of R-Ras by human DHHC19, a palmitoyl transferase with a CaaX box.
Baumgart F et al.
Biochimica Et Biophysica Acta, 2010
Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum.
McHugh BJ et al.
Journal of Cell Science, 2010
Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras.
Hodkinson PS et al.
The Journal of Biological Chemistry, 2007
Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS.
Tanaka T et al.
The Embo Journal, 2007
Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation.
Willard MD et al.
The Embo Journal, 2007
C-terminal sequences in R-Ras are involved in integrin regulation and in plasma membrane microdomain distribution.
Hansen M et al.
Biochemical and Biophysical Research Communications, 2003
Talin binding to integrin beta tails: a final common step in integrin activation.
Tadokoro S et al.
Science (new York, N.y.), 2003
A distinct class of dominant negative Ras mutants: cytosolic GTP-bound Ras effector domain mutants that inhibit Ras signaling and transformation and enhance cell adhesion.
Fiordalisi JJ et al.
The Journal of Biological Chemistry, 2002
The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function.
Oertli B et al.
Oncogene, 2000
Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck.
Braverman LE et al.
The Journal of Biological Chemistry, 1999
The Ras-related protein R-ras interacts directly with Raf-1 in a GTP-dependent manner.
Spaargaren M et al.
The Biochemical Journal, 1994