Associated Papers
Exploring the Dynamic Interplay of Deleterious Variants on the RAF1-RAP1A Binding in Cancer: Conformational Analysis, Binding Free Energy, and Essential Dynamics.
Khan A et al.
Proteins, 2025
Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation.
Czyzyk D et al.
Nature Communications, 2025
In silico identification and characterization of small-molecule inhibitors specific to RhoG/Rac1 signaling pathway.
Dipankar P et al.
Journal of Biomolecular Structure & Dynamics, 2023
RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway.
Dhanaraman T et al.
Science Signaling, 2020
Development of Noonan syndrome by deregulation of allosteric SOS autoactivation.
Umutesi HG et al.
The Journal of Biological Chemistry, 2020
A conserved, N-terminal tyrosine signal directs Ras for inhibition by Rabex-5.
Washington C et al.
Plos Genetics, 2020
Cysteine-based regulation of redox-sensitive Ras small GTPases.
Messina S et al.
Redox Biology, 2019
Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem.
Gingras AR et al.
The Journal of Cell Biology, 2019
Rap2 and TNIK control Plexin-dependent tiled synaptic innervation in C. elegans.
Chen X et al.
Elife, 2018
Distinct dynamics and interaction patterns in H- and K-Ras oncogenic P-loop mutants.
Sayyed-Ahmad A et al.
Proteins, 2017
New insights into the molecular mechanism of the Rab GTPase Sec4p activation.
Rinaldi FC et al.
Bmc Structural Biology, 2015
RalGDS family members couple Ras to Ral signalling and that's not all.
Ferro E et al.
Cellular Signalling, 2010
M-Ras is activated by bone morphogenetic protein-2 and participates in osteoblastic determination, differentiation, and transdifferentiation.
Watanabe-Takano H et al.
Experimental Cell Research, 2010
Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum.
McHugh BJ et al.
Journal of Cell Science, 2010
Detection of K-Ras mutations in tumour samples of patients with non-small cell lung cancer using PNA-mediated PCR clamping.
Beau-Faller M et al.
British Journal of Cancer, 2009
Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras.
Hodkinson PS et al.
The Journal of Biological Chemistry, 2007
Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac.
Dupuy AG et al.
Oncogene, 2005
Conformational states of Ras complexed with the GTP analogue GppNHp or GppCH2p: implications for the interaction with effector proteins.
Spoerner M et al.
Biochemistry, 2005
Rapid detection of K-ras mutations in bile by peptide nucleic acid-mediated PCR clamping and melting curve analysis: comparison with restriction fragment length polymorphism analysis.
Chen CY et al.
Clinical Chemistry, 2004
Expression of activated M-Ras in a murine mammary epithelial cell line induces epithelial-mesenchymal transition and tumorigenesis.
Ward KR et al.
Oncogene, 2004
C-terminal sequences in R-Ras are involved in integrin regulation and in plasma membrane microdomain distribution.
Hansen M et al.
Biochemical and Biophysical Research Communications, 2003
Ras superfamily monomeric G proteins in carcinoma cell motility.
Oxford G et al.
Cancer Letters, 2003
The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function.
Oertli B et al.
Oncogene, 2000
RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao.
Traver S et al.
The Biochemical Journal, 2000
Structural differences between valine-12 and aspartate-12 Ras proteins may modify carcinoma aggression.
Al-Mulla F et al.
The Journal of Pathology, 1999
Novel Cdc42-binding proteins Gic1 and Gic2 control cell polarity in yeast.
Brown JL et al.
Genes & Development, 1997
A mechanism of Bud1p GTPase action suggested by mutational analysis and immunolocalization.
Michelitch M et al.
Current Biology : Cb, 1996
Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity.
Gideon P et al.
Molecular and Cellular Biology, 1992