Associated Papers
Whole genome sequencing approach to assess homologous recombination deficiency in a pan-cancer cohort.
Al Assaad M et al.
Communications Medicine, 2026
Fetal Macrocephaly: Prenatal Findings and Follow-Up in Cases With High Risk for Abnormal Outcome.
Miremberg H et al.
Prenatal Diagnosis, 2026
The small GTPase MRAS is a broken switch.
Bernal Astrain G et al.
Nature Communications, 2025
Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation.
Czyzyk D et al.
Nature Communications, 2025
Unmutated RRAS2 emerges as a key oncogene in post-partum-associated triple negative breast cancer.
Cifuentes C et al.
Molecular Cancer, 2024
RAS and SHOC2 Roles in RAF Activation and Therapeutic Considerations.
Bonsor DA et al.
Annual Review of Cancer Biology, 2024
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy.
Holderfield M et al.
Nature, 2024
The RRAS2 pathogenic variant (c.67G>T; p. Gly23Cys) produces Noonan syndrome with embryonal rhabdomyosarcoma.
Zeng L et al.
Molecular Genetics & Genomic Medicine, 2024
Functional analysis of RRAS2 pathogenic variants with a Noonan-like phenotype.
Iida T et al.
Frontiers in Genetics, 2024
Identification of a novel frameshift variation in ANKRD11: a case report of KBG syndrome.
Shao Q et al.
Frontiers in Genetics, 2024
Mice Overexpressing Wild-Type RRAS2 Are a Novel Model for Preclinical Testing of Anti-Chronic Lymphocytic Leukemia Therapies.
Hortal AM et al.
Cancers, 2023
Characterization of Three Somatic Mutations in the 3'UTR of RRAS2 and Their Inverse Correlation with Lymphocytosis in Chronic Lymphocytic Leukemia.
Lacuna M et al.
Cells, 2023
Gastric cancer with distinct Epstein-Barr virus-positive and -negative tumor components and their whole exome sequencing result: a case Report.
Park KB et al.
Diagnostic Pathology, 2023
An Optimized Single Nucleotide Polymorphism-Based Detection Method Suggests That Allelic Variants in the 3' Untranslated Region of RRAS2 Correlate with Treatment Response in Chronic Lymphocytic Leukemia Patients.
Hortal A et al.
Cancers, 2023
Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors.
Clavaín L et al.
Oncogene, 2023
The molecular genetics of RASopathies: An update on novel disease genes and new disorders.
Tartaglia M et al.
American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, 2022
Are transient protein-protein interactions more dispensable?
Ghadie MA et al.
Plos Computational Biology, 2022
Genomic characterization of intracranial teratomas using whole genome sequencing.
Zhang C et al.
Frontiers in Oncology, 2022
Mutation Edgotype Drives Fitness Effect in Human.
Ghadie M et al.
Frontiers in Bioinformatics, 2021
Activating Mutations of RRAS2 Are a Rare Cause of Noonan Syndrome.
Capri Y et al.
American Journal of Human Genetics, 2019
ERK1/2-induced phosphorylation of R-Ras GTPases stimulates their oncogenic potential.
Frémin C et al.
Oncogene, 2016
R-Ras controls axon branching through afadin in cortical neurons.
Iwasawa N et al.
Molecular Biology of the Cell, 2012
Signaling pathways regulating TC21-induced tumorigenesis.
Erdogan M et al.
The Journal of Biological Chemistry, 2007
Ras superfamily monomeric G proteins in carcinoma cell motility.
Oxford G et al.
Cancer Letters, 2003
Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells.
Rosário M et al.
The Embo Journal, 1999