Associated Papers
Targeting 14-3-3θ-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia mice.
Ke YD et al.
Neuron, 2024
Intracellular Conformation of Amyotrophic Lateral Sclerosis-Causative TDP-43.
Kitamura A et al.
International Journal of Molecular Sciences, 2023
Specific RNA interactions promote TDP-43 multivalent phase separation and maintain liquid properties.
Grese ZR et al.
Embo Reports, 2021
Molecular Mechanisms Underlying TDP-43 Pathology in Cellular and Animal Models of ALS and FTLD.
Wood A et al.
International Journal of Molecular Sciences, 2021
Amyotrophic Lateral Sclerosis Genes in Drosophila melanogaster.
Layalle S et al.
International Journal of Molecular Sciences, 2021
The debated toxic role of aggregated TDP-43 in amyotrophic lateral sclerosis: a resolution in sight?
Hergesheimer RC et al.
Brain : a Journal of Neurology, 2019
TDP-43 post-translational modifications in health and disease.
Buratti E
Expert Opinion on Therapeutic Targets, 2018
Structural analysis of disease-related TDP-43 D169G mutation: linking enhanced stability and caspase cleavage efficiency to protein accumulation.
Chiang CH et al.
Scientific Reports, 2016
ALS-linked mutations enlarge TDP-43-enriched neuronal RNA granules in the dendritic arbor.
Liu-Yesucevitz L et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2014
Similar dose-dependence of motor neuron cell death caused by wild type human TDP-43 and mutants with ALS-associated amino acid substitutions.
Wu LS et al.
Journal of Biomedical Science, 2013
Aberrant assembly of RNA recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein of 43 kDa (TDP-43).
Shodai A et al.
The Journal of Biological Chemistry, 2013
Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a Drosophila model of amyotrophic lateral sclerosis.
Estes PS et al.
Disease Models & Mechanisms, 2013
Accelerated disease onset with stabilized familial amyotrophic lateral sclerosis (ALS)-linked mutant TDP-43 proteins.
Watanabe S et al.
The Journal of Biological Chemistry, 2013
Drosophila Answers to TDP-43 Proteinopathies.
Romano M et al.
Journal of Amino Acids, 2012
The role of mutant TAR DNA-binding protein 43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Janssens J et al.
Biochemical Society Transactions, 2011
Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis.
Barmada SJ et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2010
TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis.
Kabashi E et al.
Nature Genetics, 2008