Associated Papers
Aicardi-Goutières Syndrome caused by SAMHD1 mutation: Pathogenesis and Beyond.
Li Y et al.
Clinical Immunology (orlando, Fla.), 2026
SAMHD1 shapes deoxynucleotide triphosphate homeostasis by interconnecting the depletion and biosynthesis of different dNTPs.
McCown C et al.
Nature Communications, 2025
Acetylation of SAMHD1 at lysine 580 is crucial for blocking HIV-1 infection.
Bulnes-Ramos A et al.
Mbio, 2024
Allosteric substrate activation of SAMHD1 shapes deoxynucleotide triphosphate imbalances by interconnecting the depletion and biosynthesis of different dNTPs.
McCown C et al.
Biorxiv : the Preprint Server for Biology, 2023
Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction and cellular dNTP levels.
Schüssler M et al.
Biorxiv : the Preprint Server for Biology, 2023
SAMHD1 in cancer: curse or cure?
Schott K et al.
Journal of Molecular Medicine (berlin, Germany), 2022
Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins.
Bowen NE et al.
The Journal of Biological Chemistry, 2021
Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.
Yu CH et al.
Nature Communications, 2021
SAMHD1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination.
Husain A et al.
The Embo Journal, 2020
Defective modulation of LINE-1 retrotransposition by cancer-associated SAMHD1 mutants.
Gao W et al.
Biochemical and Biophysical Research Communications, 2019
The missing link: allostery and catalysis in the anti-viral protein SAMHD1.
Morris ER et al.
Biochemical Society Transactions, 2019
Functionality of Redox-Active Cysteines Is Required for Restriction of Retroviral Replication by SAMHD1.
Wang Z et al.
Cell Reports, 2018
SAMHD1 protects cancer cells from various nucleoside-based antimetabolites.
Herold N et al.
Cell Cycle (georgetown, Tex.), 2017
A SAMHD1 mutation associated with Aicardi-Goutières syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans.
White TE et al.
Human Mutation, 2017
Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect.
Bhattacharya A et al.
Scientific Reports, 2016
Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle.
Sommer AF et al.
Scientific Reports, 2016
The ribonuclease activity of SAMHD1 is required for HIV-1 restriction.
Ryoo J et al.
Nature Medicine, 2014
Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutières syndrome-related SAMHD1.
Zhao K et al.
Cell Reports, 2013