Associated Papers
Prenatal Diagnosis of Malformations of Cortical Development: A Review of Genetic and Imaging Advances.
Hu J et al.
Biomedicines, 2026
Malformations of cortical development: Fetal imaging and genetics.
Wang LL et al.
Molecular Genetics & Genomic Medicine, 2024
Biochemical functions and structure of Caenorhabditis elegans ZK177.8 protein: Aicardi-Goutières syndrome SAMHD1 dNTPase ortholog.
Maehigashi T et al.
The Journal of Biological Chemistry, 2023
SAMHD1 in cancer: curse or cure?
Schott K et al.
Journal of Molecular Medicine (berlin, Germany), 2022
Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins.
Bowen NE et al.
The Journal of Biological Chemistry, 2021
Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells.
Bosso M et al.
Plos Pathogens, 2020
Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.
Morris ER et al.
Nature Communications, 2020
The dNTPase activity of SAMHD1 is important for its suppression of innate immune responses in differentiated monocytic cells.
Qin Z et al.
The Journal of Biological Chemistry, 2020
Structural characterization and directed modification of Sus scrofa SAMHD1 reveal the mechanism underlying deoxynucleotide regulation.
Kong J et al.
The Febs Journal, 2019
The missing link: allostery and catalysis in the anti-viral protein SAMHD1.
Morris ER et al.
Biochemical Society Transactions, 2019
A Cyclin-Binding Motif in Human SAMHD1 Is Required for Its HIV-1 Restriction, dNTPase Activity, Tetramer Formation, and Efficient Phosphorylation.
St Gelais C et al.
Journal of Virology, 2018
A central role for PI3K-AKT signaling pathway in linking SAMHD1-deficiency to the type I interferon signature.
Oh C et al.
Scientific Reports, 2018
The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation.
Herrmann A et al.
Mobile Dna, 2018
A Putative Cyclin-binding Motif in Human SAMHD1 Contributes to Protein Phosphorylation, Localization, and Stability.
St Gelais C et al.
The Journal of Biological Chemistry, 2016
Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592.
Tang C et al.
The Journal of Biological Chemistry, 2015
Structural basis of allosteric activation of sterile α motif and histidine-aspartate domain-containing protein 1 (SAMHD1) by nucleoside triphosphates.
Koharudin LM et al.
The Journal of Biological Chemistry, 2014
The ribonuclease activity of SAMHD1 is required for HIV-1 restriction.
Ryoo J et al.
Nature Medicine, 2014
Mechanism of allosteric activation of SAMHD1 by dGTP.
Ji X et al.
Nature Structural & Molecular Biology, 2013