Associated Papers
Biochemical functions and structure of Caenorhabditis elegans ZK177.8 protein: Aicardi-Goutières syndrome SAMHD1 dNTPase ortholog.
Maehigashi T et al.
The Journal of Biological Chemistry, 2023
SAMHD1 in cancer: curse or cure?
Schott K et al.
Journal of Molecular Medicine (berlin, Germany), 2022
Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins.
Bowen NE et al.
The Journal of Biological Chemistry, 2021
Dual roles of SAMHD1 in tumor development and chemoresistance to anticancer drugs.
Chen Z et al.
Oncology Letters, 2021
Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.
Morris ER et al.
Nature Communications, 2020
The dNTPase activity of SAMHD1 is important for its suppression of innate immune responses in differentiated monocytic cells.
Qin Z et al.
The Journal of Biological Chemistry, 2020
Structural characterization and directed modification of Sus scrofa SAMHD1 reveal the mechanism underlying deoxynucleotide regulation.
Kong J et al.
The Febs Journal, 2019
The missing link: allostery and catalysis in the anti-viral protein SAMHD1.
Morris ER et al.
Biochemical Society Transactions, 2019
A Cyclin-Binding Motif in Human SAMHD1 Is Required for Its HIV-1 Restriction, dNTPase Activity, Tetramer Formation, and Efficient Phosphorylation.
St Gelais C et al.
Journal of Virology, 2018
A Putative Cyclin-binding Motif in Human SAMHD1 Contributes to Protein Phosphorylation, Localization, and Stability.
St Gelais C et al.
The Journal of Biological Chemistry, 2016
Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592.
Tang C et al.
The Journal of Biological Chemistry, 2015
Structural basis of allosteric activation of sterile α motif and histidine-aspartate domain-containing protein 1 (SAMHD1) by nucleoside triphosphates.
Koharudin LM et al.
The Journal of Biological Chemistry, 2014
SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.
Clifford R et al.
Blood, 2014
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