Associated Papers
Hepatocyte SAMHD1 Deficiency Attenuates Hepatic Steatosis via Suppression of SREBP Activation in a Mouse Model of Metabolic-Associated Steatotic Liver Disease.
Yin G et al.
International Journal of Biological Sciences, 2026
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses.
Sun J et al.
Signal Transduction and Targeted Therapy, 2025
Human papillomavirus 16 replication converts SAMHD1 into a homologous recombination factor and promotes its recruitment to replicating viral DNA.
James CD et al.
Journal of Virology, 2024
Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction and cellular dNTP levels.
Schüssler M et al.
Biorxiv : the Preprint Server for Biology, 2023
SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA.
Maharana S et al.
Molecular Cell, 2022
SAMHD1 in cancer: curse or cure?
Schott K et al.
Journal of Molecular Medicine (berlin, Germany), 2022
SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells.
Martinat C et al.
Nature Communications, 2021
SAMHD1 Inhibits Multiple Enteroviruses by Interfering with the Interaction between VP1 and VP2 Proteins.
Zhao Z et al.
Journal of Virology, 2021
Dual roles of SAMHD1 in tumor development and chemoresistance to anticancer drugs.
Chen Z et al.
Oncology Letters, 2021
SAMHD1 Phosphorylation at T592 Regulates Cellular Localization and S-phase Progression.
Batalis S et al.
Frontiers in Molecular Biosciences, 2021
SAMHD1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination.
Husain A et al.
The Embo Journal, 2020
Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells.
Bosso M et al.
Plos Pathogens, 2020
Involvement of SAMHD1 in dNTP homeostasis and the maintenance of genomic integrity and oncotherapy (Review).
Zhang Z et al.
International Journal of Oncology, 2020
Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy.
Rudd SG et al.
Embo Molecular Medicine, 2020
Human cytomegalovirus overcomes SAMHD1 restriction in macrophages via pUL97.
Businger R et al.
Nature Microbiology, 2019
Defective modulation of LINE-1 retrotransposition by cancer-associated SAMHD1 mutants.
Gao W et al.
Biochemical and Biophysical Research Communications, 2019
SAMHD1 Posttranscriptionally Controls the Expression of Foxp3 and Helios in Human T Regulatory Cells.
Kim YC et al.
Journal of Immunology (baltimore, Md. : 1950), 2018
SAMHD1 acts at stalled replication forks to prevent interferon induction.
Coquel F et al.
Nature, 2018
A Cyclin-Binding Motif in Human SAMHD1 Is Required for Its HIV-1 Restriction, dNTPase Activity, Tetramer Formation, and Efficient Phosphorylation.
St Gelais C et al.
Journal of Virology, 2018
The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation.
Herrmann A et al.
Mobile Dna, 2018
The dNTP triphosphohydrolase activity of SAMHD1 persists during S-phase when the enzyme is phosphorylated at T592.
Tramentozzi E et al.
Cell Cycle (georgetown, Tex.), 2018
SAMHD1 is active in cycling cells permissive to HIV-1 infection.
Badia R et al.
Antiviral Research, 2017
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.
Herold N et al.
Nature Medicine, 2017
A Highly Active Isoform of Lentivirus Restriction Factor SAMHD1 in Mouse.
Bloch N et al.
The Journal of Biological Chemistry, 2017
Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle.
Sommer AF et al.
Scientific Reports, 2016
CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain.
Yan J et al.
The Journal of Biological Chemistry, 2015
Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells.
Pauls E et al.
Journal of Immunology (baltimore, Md. : 1950), 2014
Identification of cellular proteins interacting with the retroviral restriction factor SAMHD1.
St Gelais C et al.
Journal of Virology, 2014
Restriction of virus infection but not catalytic dNTPase activity is regulated by phosphorylation of SAMHD1.
Welbourn S et al.
Journal of Virology, 2013