Associated Papers
Acetylation of SAMHD1 at lysine 580 is crucial for blocking HIV-1 infection.
Bulnes-Ramos A et al.
Mbio, 2024
Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.
Zhang SM et al.
Iscience, 2024
Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.
Yu CH et al.
Nature Communications, 2021
Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy.
Rudd SG et al.
Embo Molecular Medicine, 2020
Functionality of Redox-Active Cysteines Is Required for Restriction of Retroviral Replication by SAMHD1.
Wang Z et al.
Cell Reports, 2018
A Cyclin-Binding Motif in Human SAMHD1 Is Required for Its HIV-1 Restriction, dNTPase Activity, Tetramer Formation, and Efficient Phosphorylation.
St Gelais C et al.
Journal of Virology, 2018
Uncovering allostery and regulation in SAMHD1 through molecular dynamics simulations.
Patra KK et al.
Proteins, 2017
A SAMHD1 mutation associated with Aicardi-Goutières syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans.
White TE et al.
Human Mutation, 2017
Modulation of LINE-1 Retrotransposition by a Human SAMHD1 Polymorphism.
White TE et al.
Virology Reports, 2016
Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect.
Bhattacharya A et al.
Scientific Reports, 2016
CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain.
Yan J et al.
The Journal of Biological Chemistry, 2015
Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility.
White TE et al.
Virology, 2014
Contribution of oligomerization to the anti-HIV-1 properties of SAMHD1.
Brandariz-Nuñez A et al.
Retrovirology, 2013
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