Associated Papers
Reaction Mechanism and Metal Selectivity of Human SAMHD1 Elucidated by QM/MM Calculations.
Deng WH et al.
Acs Catalysis, 2025
Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1.
Orris B et al.
Nucleic Acids Research, 2023
Deoxyguanosine-Linked Bifunctional Inhibitor of SAMHD1 dNTPase Activity and Nucleic Acid Binding.
Egleston M et al.
Acs Chemical Biology, 2023
Guanine-containing ssDNA and RNA induce dimeric and tetrameric SAMHD1 in cryo-EM and binding studies.
Orris B et al.
Biorxiv : the Preprint Server for Biology, 2023
SAMHD1 in cancer: curse or cure?
Schott K et al.
Journal of Molecular Medicine (berlin, Germany), 2022
Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp- and Sp-dNTPαS Diastereomers.
Morris ER et al.
Biochemistry, 2021
SAMHD1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination.
Husain A et al.
The Embo Journal, 2020
Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.
Morris ER et al.
Nature Communications, 2020
Structural characterization and directed modification of Sus scrofa SAMHD1 reveal the mechanism underlying deoxynucleotide regulation.
Kong J et al.
The Febs Journal, 2019
SAMHD1 Posttranscriptionally Controls the Expression of Foxp3 and Helios in Human T Regulatory Cells.
Kim YC et al.
Journal of Immunology (baltimore, Md. : 1950), 2018
A central role for PI3K-AKT signaling pathway in linking SAMHD1-deficiency to the type I interferon signature.
Oh C et al.
Scientific Reports, 2018
Roles of SAMHD1 in antiviral defense, autoimmunity and cancer.
Li M et al.
Reviews in Medical Virology, 2017
SAMHD1 protects cancer cells from various nucleoside-based antimetabolites.
Herold N et al.
Cell Cycle (georgetown, Tex.), 2017
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.
Herold N et al.
Nature Medicine, 2017
Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle.
Sommer AF et al.
Scientific Reports, 2016
The ribonuclease activity of SAMHD1 is required for HIV-1 restriction.
Ryoo J et al.
Nature Medicine, 2014
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