Associated Papers
SARM1 participates in axonal degeneration and mitochondrial dysfunction in prion disease.
Lai MY et al.
Neural Regeneration Research, 2022
SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration.
Figley MD et al.
Neuron, 2021
Structural basis for SARM1 inhibition and activation under energetic stress.
Sporny M et al.
Elife, 2020
The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration.
Essuman K et al.
Neuron, 2017
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