Associated Papers
Hypoxia-inducible factor 1 protects neurons from Sarm1-mediated neurodegeneration.
Meraner P et al.
Cell Reports, 2026
Decoding Missense Variants by Incorporating Phase Separation via Machine Learning.
Feng M et al.
Nature Communications, 2024
39333476 (PubMed )
Supplement: 41467_2024_52580_MOESM4_ESM.xlsx › impact_ps_mutations
SARM1 regulates pro-inflammatory cytokine expression in human monocytes by NADase-dependent and -independent mechanisms.
Sugisawa R et al.
Iscience, 2024
SARM1 participates in axonal degeneration and mitochondrial dysfunction in prion disease.
Lai MY et al.
Neural Regeneration Research, 2022
Natural variants of human SARM1 cause both intrinsic and dominant loss-of-function influencing axon survival.
Ademi M et al.
Scientific Reports, 2022
Divergent signaling requirements of dSARM in injury-induced degeneration and developmental glial phagocytosis.
Herrmann KA et al.
Plos Genetics, 2022
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.
Shi Y et al.
Molecular Cell, 2022
Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients.
Bloom AJ et al.
Molecular Neurodegeneration, 2022
Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1.
Loreto A et al.
Elife, 2021
Pharmacological SARM1 inhibition protects axon structure and function in paclitaxel-induced peripheral neuropathy.
Bosanac T et al.
Brain : a Journal of Neurology, 2021
Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disorders.
Gilley J et al.
Elife, 2021
A phase transition enhances the catalytic activity of SARM1, an NAD+ glycohydrolase involved in neurodegeneration.
Loring HS et al.
Elife, 2021
34184985 (PubMed )
Supplement: elife-66694-transrepform.pdf
The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative SARM1.
Jiang Y et al.
Nature, 2020
Structural basis for SARM1 inhibition and activation under energetic stress.
Sporny M et al.
Elife, 2020
TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes.
Essuman K et al.
Current Biology : Cb, 2018
The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration.
Essuman K et al.
Neuron, 2017
Cataract-related mutations in EphA2: a survey of literature data and the relevance of the receptor Sam domain.
Vincenzi M et al.
Expert Opinion on Therapeutic Targets, 0
Select a paper to view details