Associated Papers
Shared genetics in epilepsy and migraine: A scoping review.
Sahu P et al.
Epileptic Disorders : International Epilepsy Journal With Videotape, 2025
Mechanisms underlying CSD initiation implicated by genetic mouse models of migraine.
Pietrobon D et al.
The Journal of Headache and Pain, 2025
Brainstem depolarization-induced lethal apnea associated with gain-of-function SCN1AL263V is prevented by sodium channel blockade.
Jansen NA et al.
Proceedings of the National Academy of Sciences of the United States of America, 2024
Spontaneous and optogenetically induced cortical spreading depolarization in familial hemiplegic migraine type 1 mutant mice.
Loonen ICM et al.
Neurobiology of Disease, 2024
Genetic Mechanisms of Migraine: Insights from Monogenic Migraine Mutations.
Gosalia H et al.
International Journal of Molecular Sciences, 2023
Pathophysiology of migraine aura.
Sanchez Del Rio M et al.
Handbook of Clinical Neurology, 2023
Genetics of migraine: Delineation of contemporary understanding of the genetic underpinning of migraine.
de Boer I et al.
Handbook of Clinical Neurology, 2023
Gene variant effects across sodium channelopathies predict function and guide precision therapy.
Brunklaus A et al.
Brain : a Journal of Neurology, 2022
The gain of function SCN1A disorder spectrum: novel epilepsy phenotypes and therapeutic implications.
Brunklaus A et al.
Brain : a Journal of Neurology, 2022
Initiation of migraine-related cortical spreading depolarization by hyperactivity of GABAergic neurons and NaV1.1 channels.
Chever O et al.
The Journal of Clinical Investigation, 2021
Hyperexcitable interneurons trigger cortical spreading depression in an Scn1a migraine model.
Auffenberg E et al.
The Journal of Clinical Investigation, 2021
Sodium channelopathies of skeletal muscle and brain.
Mantegazza M et al.
Physiological Reviews, 2021
Cerebellar spreading depolarization mediates paroxysmal movement disorder.
Lu B et al.
Cell Reports, 2021
Epilepsy and Migraine Shared Genetic and Molecular Mechanisms: Focus on Therapeutic Strategies.
Gotra P et al.
Molecular Neurobiology, 2021
Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine.
Lemaire L et al.
Plos Computational Biology, 2021
Deciphering in silico the Role of Mutated Na V 1.1 Sodium Channels in Enhancing Trigeminal Nociception in Familial Hemiplegic Migraine Type 3.
Suleimanova A et al.
Frontiers in Cellular Neuroscience, 2021
SCN1A Mutation-Beyond Dravet Syndrome: A Systematic Review and Narrative Synthesis.
Ding J et al.
Frontiers in Neurology, 2021
Biological concepts in human sodium channel epilepsies and their relevance in clinical practice.
Brunklaus A et al.
Epilepsia, 2020
SCN1A variants from bench to bedside-improved clinical prediction from functional characterization.
Brunklaus A et al.
Human Mutation, 2020
First FHM3 mouse model shows spontaneous cortical spreading depolarizations.
Jansen NA et al.
Annals of Clinical and Translational Neurology, 2020
Gain of function of sporadic/familial hemiplegic migraine-causing SCN1A mutations: Use of an optimized cDNA.
Bertelli S et al.
Cephalalgia : an International Journal of Headache, 2019
Two novel families with hemiplegic migraine caused by recurrent SCN1A mutation p.F1499L.
Schubert V et al.
Cephalalgia : an International Journal of Headache, 2018
Familial Hemiplegic Migraine Type 3 (FHM3) With an SCN1A Mutation in a Chinese Family: A Case Report.
Shao N et al.
Frontiers in Neurology, 2018
Optimizing genomic medicine in epilepsy through a gene-customized approach to missense variant interpretation.
Traynelis J et al.
Genome Research, 2017
Genetics of Migraine: Insights into the Molecular Basis of Migraine Disorders.
Sutherland HG et al.
Headache, 2017
The genetic relationship between epilepsy and hemiplegic migraine.
Huang Y et al.
Neuropsychiatric Disease and Treatment, 2017
Animal models of monogenic migraine.
Chen SP et al.
Cephalalgia : an International Journal of Headache, 2016
Two novel SCN1A mutations identified in families with familial hemiplegic migraine.
Weller CM et al.
Cephalalgia : an International Journal of Headache, 2014
Familial hemiplegic migraine due to L263V SCN1A mutation: discordance for epilepsy between two kindreds from Douro Valley.
Barros J et al.
Cephalalgia : an International Journal of Headache, 2014
Nonfunctional NaV1.1 familial hemiplegic migraine mutant transformed into gain of function by partial rescue of folding defects.
Cestèle S et al.
Proceedings of the National Academy of Sciences of the United States of America, 2013
Pearls and pitfalls in genetic studies of migraine.
Eising E et al.
Cephalalgia : an International Journal of Headache, 2013
Ranolazine selectively blocks persistent current evoked by epilepsy-associated Naν1.1 mutations.
Kahlig KM et al.
British Journal of Pharmacology, 2010
Management of sporadic and familial hemiplegic migraine.
Russell MB
Expert Review of Neurotherapeutics, 2010
Subtype-selective targeting of voltage-gated sodium channels.
England S et al.
British Journal of Pharmacology, 2009
First mutation in the voltage-gated Nav1.1 subunit gene SCN1A with co-occurring familial hemiplegic migraine and epilepsy.
Castro MJ et al.
Cephalalgia : an International Journal of Headache, 2009
Divergent sodium channel defects in familial hemiplegic migraine.
Kahlig KM et al.
Proceedings of the National Academy of Sciences of the United States of America, 2008