Associated Papers
Voltage-Gated Sodium Channels: A Therapeutic Target in Ischemic Heart Disease.
Zhang XL et al.
Reviews in Cardiovascular Medicine, 2025
SCN5A missense variants and their contribution to deaths in Sudden Unexplained Nocturnal Death Syndrome (SUNDS).
Chaloemthanetphong A et al.
Forensic Science International. Genetics, 2025
Computational analysis of congenital heart disease associated SNPs: unveiling their impact on the gene regulatory system.
Vashisht S et al.
Bmc Genomics, 2025
Exploring Atrial Fibrillation: Understanding the Complex Relation Between Lifestyle and Genetic Factors.
Tamayo-Trujillo R et al.
Journal of Medical Cases, 2024
Genomic analysis of an Ecuadorian individual carrying an SCN5A rare variant.
Cadena-Ullauri S et al.
Bmc Cardiovascular Disorders, 2024
Screening for Rare Coding Variants That Associate With the QTc Interval in Iceland.
Sveinbjornsson G et al.
Journal of the American Heart Association, 2023
Gene variant effects across sodium channelopathies predict function and guide precision therapy.
Brunklaus A et al.
Brain : a Journal of Neurology, 2022
Genetic Causes of Cardiomyopathy in Children: First Results From the Pediatric Cardiomyopathy Genes Study.
Ware SM et al.
Journal of the American Heart Association, 2021
The role of sodium channels in sudden unexpected death in pediatrics.
Rochtus AM et al.
Molecular Genetics & Genomic Medicine, 2020
Next-generation sequencing using microfluidic PCR enrichment for molecular autopsy.
Raju H et al.
Bmc Cardiovascular Disorders, 2019
Genome sequencing as a first-line genetic test in familial dilated cardiomyopathy.
Minoche AE et al.
Genetics in Medicine : Official Journal of the American College of Medical Genetics, 2019
Assessing the Pathogenicity, Penetrance, and Expressivity of Putative Disease-Causing Variants in a Population Setting.
Wright CF et al.
American Journal of Human Genetics, 2019
Cardiomyopathy and Preeclampsia.
Gammill HS et al.
Circulation, 2018
An African loss-of-function CACNA1C variant p.T1787M associated with a risk of ventricular fibrillation.
Blancard M et al.
Scientific Reports, 2018
Feasibility of analysis of the SCN5A gene in paraffin embedded samples in sudden infant death cases at the Pretoria Medico-Legal Laboratory, South Africa.
van Deventer BS et al.
Forensic Science, Medicine, and Pathology, 2018
Mechanisms Underlying the Actions of Antidepressant and Antipsychotic Drugs That Cause Sudden Cardiac Arrest.
Sicouri S et al.
Arrhythmia & Electrophysiology Review, 2018
Genetic risk stratification in cardiac arrhythmias.
Napolitano C et al.
Current Opinion in Cardiology, 2018
SCN5A Variants: Association With Cardiac Disorders.
Li W et al.
Frontiers in Physiology, 2018
Genetics of sudden cardiac death - An epidemiologic perspective.
Kääb S
International Journal of Cardiology, 2017
Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans.
Evans DS et al.
Human Molecular Genetics, 2016
Is There a Role for Genetics in the Prevention of Sudden Cardiac Death?
Faragli A et al.
Journal of Cardiovascular Electrophysiology, 2016
Common human ANK2 variant confers in vivo arrhythmia phenotypes.
Musa H et al.
Heart Rhythm, 2016
Arrhythmias: Opening Pandora's Box -- incidental genetic findings.
Behr ER et al.
Nature Reviews. Cardiology, 2016
The cardiac sodium channel gene SCN5A and its gene product NaV1.5: Role in physiology and pathophysiology.
Veerman CC et al.
Gene, 2015
A common SCN5A variant is associated with PR interval and atrial fibrillation among African Americans.
Ilkhanoff L et al.
Journal of Cardiovascular Electrophysiology, 2014
Sequencing of SCN5A identifies rare and common variants associated with cardiac conduction: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.
Magnani JW et al.
Circulation. Cardiovascular Genetics, 2014
The genetics of pro-arrhythmic adverse drug reactions.
Petropoulou E et al.
British Journal of Clinical Pharmacology, 2014
Cardiac channelopathy testing in 274 ethnically diverse sudden unexplained deaths.
Wang D et al.
Forensic Science International, 2014
Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease.
Cooper DN et al.
Human Genetics, 2013
A study of the SCN5A gene in a cohort of 76 patients with Brugada syndrome.
García-Molina E et al.
Clinical Genetics, 2013
Founder mutations characterise the mutation panorama in 200 Swedish index cases referred for Long QT syndrome genetic testing.
Stattin EL et al.
Bmc Cardiovascular Disorders, 2012
Clinical and genetic determinants of torsade de pointes risk.
Sauer AJ et al.
Circulation, 2012
The genetics of sudden cardiac death.
Arking DE et al.
Annual Review of Genomics and Human Genetics, 2012
Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro.
Watanabe H et al.
Circulation, 2011
SCN5A variation is associated with electrocardiographic traits in the Jackson Heart Study.
Jeff JM et al.
Circulation. Cardiovascular Genetics, 2011
Cardiac channelopathies and sudden infant death syndrome.
Tfelt-Hansen J et al.
Cardiology, 2011
Genetics of sudden death.
Naik N et al.
The Indian Journal of Medical Research, 2010
SCN5A allelic expression imbalance in African-Americans heterozygous for the common variant p.Ser1103Tyr.
Killen SA et al.
Bmc Medical Genetics, 2010
Genomics, heart failure and sudden cardiac death.
Darbar D
Heart Failure Reviews, 2010
When is genetic testing useful in patients suspected to have inherited cardiac arrhythmias?
Fowler SJ et al.
Current Opinion in Cardiology, 2010
An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing.
Kapplinger JD et al.
Heart Rhythm, 2010
Latent genetic backgrounds and molecular pathogenesis in drug-induced long-QT syndrome.
Itoh H et al.
Circulation. Arrhythmia and Electrophysiology, 2009
Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae.
Smith JG et al.
Heart Rhythm, 2009
Common variants at ten loci influence QT interval duration in the QTGEN Study.
Newton-Cheh C et al.
Nature Genetics, 2009
Sudden infant death syndrome: do ion channels play a role?
Van Norstrand DW et al.
Heart Rhythm, 2009
Genetic determinants of sudden cardiac death.
Noseworthy PA et al.
Circulation, 2008
Overrepresentation of the proarrhythmic, sudden death predisposing sodium channel polymorphism S1103Y in a population-based cohort of African-American sudden infant death syndrome.
Van Norstrand DW et al.
Heart Rhythm, 2008