Associated Papers
Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core Complex.
Lin LL et al.
Nature Communications, 2026
Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core Complex.
Lin LL et al.
Biorxiv : the Preprint Server for Biology, 2025
E3 ubiquitin ligase SYVN1 as a promising therapeutic target for diverse human diseases.
Zhu L et al.
Pharmacological Research, 2025
Purkinje cell-specific deficiency in SEL1L-hrd1 endoplasmic reticulum-associated degradation causes progressive cerebellar ataxia in mice.
Torres M et al.
Jci Insight, 2024
Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders.
Wang HH et al.
The Journal of Clinical Investigation, 2024
Biallelic Cys141Tyr variant of SEL1L is associated with neurodevelopmental disorders, agammaglobulinemia, and premature death.
Weis D et al.
The Journal of Clinical Investigation, 2024
Hypomorphic human SEL1L and HRD1 variants uncouple multilayered ER-associated degradation machinery.
Umphred-Wilson K et al.
The Journal of Clinical Investigation, 2024
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