Associated Papers
Neuronal SEL1L-HRD1 ER-associated degradation is essential for motor function and survival in mice.
Torres M et al.
The Journal of Clinical Investigation, 2026
Ubiquitination by HRD1 is essential for TLR3 trafficking and its innate immune signaling.
Zhao L et al.
Nature Communications, 2025
41372171 (PubMed )
Supplement: 41467_2025_67219_MOESM3_ESM.pdf
A molecular switch in NAC prevents mitochondrial protein mistargeting by SRP.
Maldosevic E et al.
Biorxiv : the Preprint Server for Biology, 2025
Functional rescue of a fatal ERAD mutation via alternative splicing.
Wang HH et al.
Biorxiv : the Preprint Server for Biology, 2025
Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core Complex.
Lin LL et al.
Biorxiv : the Preprint Server for Biology, 2025
Regulation of leptin signaling and diet-induced obesity by SEL1L-HRD1 ER-associated degradation in POMC expressing neurons.
Mao H et al.
Nature Communications, 2024
39343970 (PubMed )
Supplement: 41467_2024_52743_MOESM3_ESM.pdf
Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders.
Wang HH et al.
The Journal of Clinical Investigation, 2024
Biallelic Cys141Tyr variant of SEL1L is associated with neurodevelopmental disorders, agammaglobulinemia, and premature death.
Weis D et al.
The Journal of Clinical Investigation, 2024
Hypomorphic human SEL1L and HRD1 variants uncouple multilayered ER-associated degradation machinery.
Umphred-Wilson K et al.
The Journal of Clinical Investigation, 2024
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