Associated Papers
Cholesterol accumulation impairs HIF-1α-dependent immunometabolic reprogramming of LPS-stimulated macrophages by upregulating the NRF2 pathway.
Ting KKY et al.
Scientific Reports, 2024
Degradation-Resistant Hypoxia Inducible Factor-2α in Murine Osteocytes Promotes a High Bone Mass Phenotype.
Mendoza SV et al.
Jbmr Plus, 2023
HIF-1 maintains a functional relationship between pancreatic cancer cells and stromal fibroblasts by upregulating expression and secretion of Sonic hedgehog.
Katagiri T et al.
Oncotarget, 2018
LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis.
Yeom CJ et al.
Oncotarget, 2016
Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression.
Chou TF et al.
Nature Communications, 2016
27312851 (PubMed )
Supplement: ncomms11904-s1.pdf
Sirtuin-7 inhibits the activity of hypoxia-inducible factors.
Hubbi ME et al.
The Journal of Biological Chemistry, 2013
Astrocyte pVHL and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye.
Kurihara T et al.
The Journal of Cell Biology, 2011
LW6, a novel HIF-1 inhibitor, promotes proteasomal degradation of HIF-1alpha via upregulation of VHL in a colon cancer cell line.
Lee K et al.
Biochemical Pharmacology, 2010
COMMD1 Promotes pVHL and O2-Independent Proteolysis of HIF-1alpha via HSP90/70.
van de Sluis B et al.
Plos One, 2009
An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha.
Koivunen P et al.
The Journal of Biological Chemistry, 2007
Regulated function of the prolyl-4-hydroxylase domain (PHD) oxygen sensor proteins.
Nytko KJ et al.
Antioxidants & Redox Signaling, 2007
The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases.
Koivunen P et al.
The Journal of Biological Chemistry, 2006
Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.
Huang J et al.
The Journal of Biological Chemistry, 2002
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