Associated Papers
The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Rudolf AF et al.
Nature Chemical Biology, 2019
SHH E176/E177-Zn2+ conformation is required for signaling at endogenous sites.
Himmelstein DS et al.
Developmental Biology, 2017
Sonic hedgehog mutations identified in holoprosencephaly patients can act in a dominant negative manner.
Singh S et al.
Human Genetics, 2009
Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog.
Buglino JA et al.
The Journal of Biological Chemistry, 2008
Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity.
Williams KP et al.
Journal of Cell Science, 1999
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