Associated Papers
Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.
Bonsor DA et al.
Nature Structural & Molecular Biology, 2022
Structural basis for SHOC2 modulation of RAS signalling.
Liau NPD et al.
Nature, 2022
Structure of the MRAS-SHOC2-PP1C phosphatase complex.
Hauseman ZJ et al.
Nature, 2022
SHOC2 complex-driven RAF dimerization selectively contributes to ERK pathway dynamics.
Boned Del Río I et al.
Proceedings of the National Academy of Sciences of the United States of America, 2019
SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers.
Jones GG et al.
Nature Communications, 2019
SHOC2-MRAS-PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis.
Young LC et al.
Proceedings of the National Academy of Sciences of the United States of America, 2018
Functional Integration of the Conserved Domains of Shoc2 Scaffold.
Jeoung M et al.
Plos One, 2013
Shoc2 is targeted to late endosomes and required for Erk1/2 activation in EGF-stimulated cells.
Galperin E et al.
Plos One, 2012
A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.
Rodriguez-Viciana P et al.
Molecular Cell, 2006
Select a paper to view details