Associated Papers
Structural basis for SHOC2 modulation of RAS signalling.
Liau NPD et al.
Nature, 2022
Structure of the MRAS-SHOC2-PP1C phosphatase complex.
Hauseman ZJ et al.
Nature, 2022
Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.
Kwon JJ et al.
Nature, 2022
SHOC2 complex-driven RAF dimerization selectively contributes to ERK pathway dynamics.
Boned Del Río I et al.
Proceedings of the National Academy of Sciences of the United States of America, 2019
SHOC2-MRAS-PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis.
Young LC et al.
Proceedings of the National Academy of Sciences of the United States of America, 2018
A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.
Rodriguez-Viciana P et al.
Molecular Cell, 2006
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